Publications

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Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats.

Tzimou, Anastasia, et al. Biogerontology (2020)

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1) López‐Garrido L, Bañuelos‐Hernández AE, Pérez‐Hernández E, et al. Metabolic profiling of serum in patients with cartilage tumours using 1H‐NMR spectroscopy: A pilot study. Magn Reson Chem. (2020)

Cartilage‐forming lesions include tumours that can vary in severity from benign enchondromas to high‐grade malignant chondrosarcomas. Chondrosarcoma is the second most frequent malignant bone tumour, accounting for 20–30% of all malignant bone neoplasms. Surgery is the standard treatment for cartilage tumours (CTs); however, their incidental diagnosis and the difficult differentiation of low‐grade lesions like chondrosarcoma grade I from benign entities like enchondroma are challenges for clinical management. In this sense, the search for circulating biomarkers for early detection and prognosis is an ongoing interest. Targeted metabolomics is a powerful tool that can propose potential biomarkers in biological fluids as well as help to discover disturbed metabolic pathways to reveal tumour pathogenesis. In this context, the aim of this study was to investigate the 1H nuclear magnetic resonance metabolomic serum profile of patients with CTs contrasted with healthy controls. Forty‐one metabolites were identified and quantified; the multivariate statistical methods principal component analysis and partial least squares discriminant analysis reveal a clear separation of the CT group, that is, the differential metabolites that were involved in two main metabolic pathways: the taurine and hypotaurine metabolism and synthesis and degradation of ketone bodies. Our results represent preliminary work for emergent serum‐based diagnostics or prognostic methods for patients with chondrogenic tumours.

2) Zhong X, Gu L, Xiong W, Wang H, Lian D, Zheng Y, Zhou S, Zhou W, Gu J, Shen J, Wang J, Zhang G, Liu X. 1H NMR spectroscopy-based metabolic profiling of Ophiocordyceps sinensis and Cordyceps militaris in water-boiled and 50% ethanol-soaked extracts. Journal of Pharmaceutical and Biomedical Analysis (2020)

3) McClorry S, Slupsky C, Lind T, Åkeson P, Hernell O, Öhlund I. Effectiveness of vitamin D supplementation in Swedish children may be negatively impacted by BMI and serum fructose. The Journal of Nutritional Biochemistry (2020)

4) Choi Y, Lee S, Kim H, Eom J, Kim D, Lee S. The potential nutritive value of Sargassum fulvellum as a feed ingredient for ruminants. Algal Research (2020)

5) Kim S, Kim E, Shin B, Seo J, Kim Y, Lee D, Choi H. NMR-based metabolic profiling discriminates the geographical origin of raw sesame seeds. Food Control (2020)

6) Eymann C., Götze S., Bock C. et al. Thermal performance of the European flat oyster, Ostrea edulis (Linnaeus, 1758)—explaining ecological findings under climate change. Mar Biol (2020)

7) Kumari S., Goyal V., Kumaran S.S. et al. Quantitative metabolomics of saliva using proton NMR spectroscopy in patients with Parkinson’s disease and healthy controls. Neurol Sci (2020)

8) Lu Z, Wang S, Ji C, Shan X, Wu H. Evaluation of metal pollution-induced biological effects in Chinese shrimp Fenneropenaeus chinensis by NMR-based metabolomics. Marine Pollution Bulletin (2020)

9) Chen L, Zhao X, Wu J, Liu Q, Pang X, Yang H. Metabolic characterisation of eight Escherichia coli strains including "Big Six" and acidic responses of selected strains revealed by NMR spectroscopy. Food Microbiology (2020)

10) Chien C, Lin T, Chi C, Liu C. Probiotic, Bacillus subtilis E20 alters the immunity of white shrimp, Litopenaeus vannamei via glutamine metabolism and hexosamine biosynthetic pathway. Fish & Shellfish Immunology (2020)

11) Hee Chun B, Kim K, Jeong S, Jeon C. The effect of salt concentrations on the fermentation of doenjang, a traditional Korean fermented soybean paste. Food Microbiology (2020)

12) Blakebrough-Hall C., Dona A., D’occhio M.J. et al. Diagnosis of Bovine Respiratory Disease in feedlot cattle using blood 1H NMR metabolomics. Sci Rep (2020)

13) Cropotova J, Mozuraityte R, Standal I, Ojha S, Rustad T, Brijesh Tiwari. Influence of high-pressure processing on quality attributes of haddock and mackerel minces during frozen storage, and fishcakes prepared thereof. Innovative Food Science & Emerging Technologies (2020)

14) Thøgersen R, Gray N, Kuhnle G, Van Hecke T, De Smet S, Young J, Sundekilde U, Hansen A, Bertram H. Inulin-fortification of a processed meat product attenuates formation of nitroso compounds in the gut of healthy rats. Food Chemistry (2020)

Intake of red and processed meat has been suspected to increase colorectal cancer risk potentially via endogenous formation of carcinogenic N-nitroso compounds or increased lipid and protein oxidation. Here we investigated the effect of inulin fortification of a pork sausage on these parameters. For four weeks, healthy Sprague-Dawley rats (n = 30) were fed one of three diets: inulin-fortified pork sausage, control pork sausage or a standard chow diet. Fecal content of apparent total N-nitroso compounds (ATNC), nitrosothiols and nitrosyl iron compounds (FeNO) were analyzed in addition to liver metabolism and oxidation products formed in liver, plasma and diets. Intriguingly, inulin fortification reduced fecal ATNC (p = 0.03) and FeNO (p = 0.04) concentrations. The study revealed that inulin fortification of processed meat could be a strategy to reduce nitroso compounds formed endogenously after consumption.

15) Gao P, Wang L, Yang N, Wen J, Zhao M, Su G, Zhang J, Weng D. Peroxisome proliferator-activated receptor gamma (PPARγ) activation and metabolism disturbance induced by bisphenol A and its replacement analog bisphenol S using in vitro macrophages and in vivo mouse models. Environment International (2020)

16) Bao W., Huang X., Liu J., Han B., Chen, J. Influence of Lactobacillus brevis on metabolite changes in bacteria‐fermented sufu. Journal of Food Science (2020)

17) Liang R, Shao X, Shi Y, Jiang L, Han G. Antioxidant defenses and metabolic responses of blue mussels (Mytilus edulis) exposed to various concentrations of erythromycin. Science of The Total Environment (2020)

18) Alinaghi M, Nguyen D.N., Sangild P.T., Bertram H.C., Direct Implementation of Intestinal Permeability Test in NMR Metabolomics for Simultaneous Biomarker Discovery—A Feasibility Study in a Preterm Piglet Model. Metabolites (2020)

19) Muhialdin B, Kadum H, Zarei M, Hussin A. Effects of metabolite changes during lacto-fermentation on the biological activity and consumer acceptability for dragon fruit juice. LWT (2020)

20) Hong, X, Mat Isa, N, Fakurazi, S, Safinar Ismail, I. Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics. Phytochemical Analysis (2020)

21) Kim S, Kim A, Ma S, Lee W, Lee S, Yoon D, Kim D H, Kim S. Glutathione Injection Alleviates the Fluctuation of Metabolic Response under Thermal Stress in Olive Flounder. Paralichthys olivaceus. Metabolites (2020)

22) Lin C, Dong J, Wei Z, Cheng K, Li J, You S, Liu Y, Wang X, Chen Z. 1H-NMR based metabolic profiles delineate the anticancer effect of vitamin C and oxaliplatin on hepatocellular carcinoma cells. Journal of Proteome Research (2020)

23) Li A, Zhang W, Zhang L, Liu Y, Li K, Du G, Qin X. Elucidating the time-dependent changes in the urinary metabolome under doxorubicin-induced nephrotoxicity. Toxicology Letters (2020)

24) Ferdausi A, Chang X, Hall A, Jones M. Galanthamine production in tissue culture and metabolomic study on Amaryllidaceae alkaloids in Narcissus pseudonarcissus cv. Carlton. Industrial Crops and Products (2020)

25) Djukovic D, Raftery D, Gowda N. Chapter 16 - Mass spectrometry and NMR spectroscopy based quantitative metabolomics. Proteomic and Metabolomic Approaches to Biomarker Discovery (Second Edition). Academic Press (2020)

26) Lopes T, de Moraes F, Arni R, Rahal P, Calmon M. Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells. Biomedicine & Pharmacotherapy (2020)

27) Luise D, Picone G, Balzani A, Capozzi F, Bertocchi M, Salvarani C, Bosi P, Edwards S, Trevisi P. Investigation of the Defatted Colostrum 1H-NMR Metabolomics Profile of Gilts and Multiparous Sows and Its Relationship with Litter Performance. Animals (2020)

28) Zheng H, Dong B, Ning J, Shao X, Zhao L, Jiang Q, Ji H, Cai A, Xue W, Gao H. NMR-based metabolomics analysis identifies discriminatory metabolic disturbances in tissue and biofluid samples for progressive prostate cancer. Clinica Chimica Acta (2020)

29) Teng S, Aziz N, Mustafa M, Laboh R, Ismail I, Devi S. Preliminary study on the effect of endogeic earthworm on metabolic changes of blood-disease-infected banana. Archives of Phytopathology and Plant Protection (2020)

30) Rahimi R, Hajirezaee S, Pordanjani H. A 1HNMR-based molecular study of anesthesia in fish. Aquaculture (2020)

31) Leung YB, Cave NJ, Heiser A, Edwards PJB, Godfrey AJR, Wester T Metabolic and Immunological Effects of Intermittent Fasting on a Ketogenic Diet Containing Medium-Chain Triglycerides in Healthy Dogs. Front. Vet. Sci. (2020)

32) Xia J, Hu X, Huang C et al. Metabolic profiling of cold adaptation of a deep-sea psychrotolerant Microbacterium sediminis to prolonged low temperature under high hydrostatic pressure. Appl Microbiol Biotechnol (2020)

33) Hansen B, Sørensen L, Størseth T, Altin D, Gonzalez S, Skancke J, Rønsberg M, Nordtug T. The use of PAH, metabolite and lipid profiling to assess exposure and effects of produced water discharges on pelagic copepods. Science of The Total Environment (2020)

34) Kumar U, Jain A, Guleria A, Kumar V, Misra D, Goel R, Danda D, Misra R, Kumar D. Circulatory Glutamine/Glucose ratio for evaluating disease activity in Takayasu arteritis: A NMR based serum metabolomics study. Journal of Pharmaceutical and Biomedical Analysis (2020)

35) Bianchi L, Laghi L, Correani V, Schifano E, Landi C, Uccelletti D, Mattei B. A Combined Proteomics, Metabolomics and In Vivo Analysis Approach for the Characterization of Probiotics in Large-Scale Production. Biomolecules (2020)

36) Burton KJ, Krüger R, Scherz V, Münger L.H, Picone G, Vionnet N, Bertelli C, Greub G, Capozzi F, Vergères G. Trimethylamine-N-Oxide Postprandial Response in Plasma and Urine Is Lower After Fermented Compared to Non-Fermented Dairy Consumption in Healthy Adults. Nutrients (2020)

37) Gramatyka M, Boguszewicz, Ciszek M, Gabryś D, Kulik R, Sokół M. Metabolic changes in mice cardiac tissue after low-dose irradiation revealed by 1H NMR spectroscopy. Journal of Radiation Research (2020)

38) Awin T, Mediani A, Faudzi S, Maulidiani, Leong S, Shaari K, Abas F. Identification of α-glucosidase inhibitory compounds from Curcuma mangga fractions, International Journal of Food Properties (2020)

39) Gao J, Bai P, Li Y, Li J, Jia C, Wang T, Zhao H, Si Y, Chen J. Metabolomic Profiling of the Synergistic Effects of Ginsenoside Rg1 in Combination with Neural Stem Cell Transplantation in Ischemic Stroke Rats. Journal of Proteome Research (2020)

40) Hsu WH, Wang S.-J., Chao Y.-M., Chen C.-J., Wang Y.-F., Fuh J.-L, Lin Y.-L. Urine metabolomics signatures in reversible cerebral vasoconstriction syndrome. Cephalalgia. (2020)

41) Gómez E, Salvetti P, Gatien J, Carrocera S, Martin-Gonzalez D, Muñoz M. BLOOD PLASMA METABOLOMICS PREDICTS PREGNANCY IN HOLSTEIN CATTLE TRANSFERRED WITH FRESH AND VITRIFIED/WARMED EMBRYOS PRODUCED IN VITRO. Journal of Proteome Research (2020)

42) Okumu D, Aponte-Collazo L, Dewar B, Cox N, East M, Tech K, McDonald I, Tikunov A, Holmuhamedov E, Macdonald J, Graves L. Lyn regulates creatine uptake in an imatinib-resistant CML cell line. Biochimica et Biophysica Acta (2020)

43) Zolkeflee NKZ, Isamail NA, Maulidiani M, et al. Metabolite variations and antioxidant activity of Muntingia calabura leaves in response to different drying methods and ethanol ratios elucidated by NMR‐based metabolomics. Phytochemical Analysis. (2020)

44) Ten-Doménech I, Ramos-Garcia V, Piñeiro-Ramos J.D, Gormaz M, Parra-Llorca A, Vento M, Kuligowski J, Quintás G. Current Practice in Untargeted Human Milk Metabolomics. Metabolites (2020)

45) van Schadewijk R., Krug J.R., Shen D. et al. Magnetic Resonance Microscopy at Cellular Resolution and Localised Spectroscopy of Medicago truncatula at 22.3 Tesla. Sci Rep 10, 971 (2020)

46) Guirro M, Gual-Grau A, Gibert-Ramos A, Alcaide-Hidalgo J.M., Canela N.; Arola L., Mayneris-Perxachs J. Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of Hesperidin Supplementation in Rats Fed an Obesogenic Diet. Antioxidants (2020)

47) Pathmasiri W., Kay K., McRitchie S., Sumner S. Analysis of NMR Metabolomics Data. In: Li S. (eds) Computational Methods and Data Analysis for Metabolomics. Methods in Molecular Biology (2020)

48) Duan X, Zhang T, Ou L et al. 1H NMR-based metabolomic study of metabolic profiling for the urine of kidney stone patients. Urolithiasis (2020)

49) Yin X, Gibbons H, Rundle M, Frost G, McNulty B A, Nugent A P, Walton J, Flynn A, Brennan L. The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide. Mol. Nutr. Food Res. (2020)

50) Maulidiani M, Abas F, Rudiyanto R, Kadir N, Zolkeflee N, Lajis N. Analysis of urinary metabolic alteration in type 2 diabetic rats treated with metformin using the metabolomics of quantitative spectral deconvolution 1H NMR spectroscopy. Microchemical Journal (2020)

51) Castellanos L, Naranjo-Gaybor S, Forero A, Morales G, Wilson E, Ramos F, Choi Y. Metabolic fingerprinting of banana passion fruits and its correlation with quorum quenching activity. Phytochemistry (2020)

52) Antonelo D, Cônsolo N, Gómez J, Beline M, Goulart R, Corte R, Colnago L, Schilling M, Gerrard D, Silva S. Metabolite profile and consumer sensory acceptability of meat from lean Nellore and Angus × Nellore crossbreed cattle fed soybean oil. Food Research International (2020)

53) Sakaguchi C A, Nieman D C, Signini E, de Abreu R, Silva C D, Rehder-Santos P, Carosio M G A, Maria R, Dato C C, de Araújo H S S, Venâncio T, Ferreira A G, Catai A M. Chronic Influence of Inspiratory Muscle Training at Different Intensities on the Serum Metabolome. Metabolites (2020).

54) Darius T, Vergauwen M, Smith T et al. Brief O2 uploading during continuous hypothermic machine perfusion is simple yet effective oxygenation method to improve initial kidney function in a porcine autotransplant model. Am J Transplant (2020)

55) Lindqvist H, Rådjursöga M, Torstensson T, Jansson L, Ellegård L, Winkvist A. Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores, The Journal of Nutrition (2020)

56) He X, Sotelo-Orozco J, Rudolph C, Lönnerdal B and Slupsky CM. The Role of Protein and Free Amino Acids on Intake, Metabolism, and Gut Microbiome: A Comparison Between Breast-Fed and Formula-Fed Rhesus Monkey Infants. Front. Pediatr. (2020)

57) Lee J D, Kim H Y, Kang K et al. Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats. Arch Toxicol (2020)

58) Morrell A, Tripet B, Eilers B, Tegman M, Thompson D, Copié V, Burkhea d J.Copper modulates sex-specific fructose hepatoxicity in nonalcoholic fatty liver disease (NALFD) Wistar rat models. The Journal of Nutritional Biochemistry (2020)

59) Cônsolo N R B, Silva J, Buarque V L M, Higuera-Padilla A, Barbosa L, Zawadzki A, Colnago L A, Netto A S, Gerrard D E, Silva S. Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle. Metabolites (2020)

60) Alshamleh N, Krause C, Richter N, Kurrle H, Serve U, Günther H, Schwalbe. Real‐Time NMR Spectroscopy for Studying Metabolism Angew. Chem. (2020)

61) Li Z, Du Y, Yuan Y. et al. Integrated quality evaluation strategy for multi-species resourced herb medicine of Qinjiao by metabolomics analysis and genetic comparation. Chin Med (2020).

62) Velásquez-Valle R, Villa-Ruano N, Hidalgo-Martínez D, Zepeda-Vallejo L, Pérez-Hernández N, Reyes-López C, Reyes-Cervantes E, Medina-Melchor D, Becerra-Martínez E. Revealing the 1H NMR metabolome of mirasol chili peppers (Capsicum annuum) infected by Candidatus Phytoplasma trifolii. Food Research International (2020)

63) Murgia F, Corda V, Serrenti M, Usai V, Santoru ML, Hurt KJ, Passaretti M, Monni MC, Atzori L, Monni G. Seminal Fluid Metabolomic Markers of Oligozoospermic Infertility in Humans. Metabolites (2020)

64) Steward KF, Eilers B, Tripet B, Fuchs A, Dorle M, Rawle R, Soriano B, Balasubramanian N, Copié V, Bothner B and Hatzenpichler R. Metabolic Implications of Using BioOrthogonal Non-Canonical Amino Acid Tagging (BONCAT) for Tracking Protein Synthesis. Front. Microbiol(2020)

BioOrthogonal Non-Canonical Amino acid Tagging (BONCAT) is a powerful tool for tracking protein synthesis on the level of single cells within communities and whole organisms. A basic premise of BONCAT is that the non-canonical amino acids (NCAA) used to track translational activity do not significantly alter cellular physiology. If the NCAA would induce changes in the metabolic state of cells, interpretation of BONCAT studies could be challenging. To address this knowledge-gap, we have used a global metabolomics analyses to assess the intracellular effects of NCAA incorporation. Two NCAA were tested: L-azidohomoalanine (AHA) and L-homopropargylglycine (HPG); L-methionine (MET) was used as a minimal stress baseline control. Liquid Chromatography Mass Spectrometry (LC-MS) and Nuclear Magnetic Resonance (NMR) were used to characterize intracellular metabolite profiles of Escherichia coli cultures, with multivariate statistical analysis using XCMS and MetaboAnalyst. Results show that doping with NCAA induces metabolic changes, however, the metabolic impact was not dramatic. A second set of experiments in which cultures were placed under mild stress to simulate real-world environmental conditions showed a more consistent and more robust perturbation. Pathways that changed include amino acid and protein synthesis, choline and betaine, and the TCA cycle. Globally, these changes were statistically minor, indicating that NCAA are unlikely to exert a significant impact on cells during incorporation. Our results are consistent with previous reports of NCAA doping under replete conditions and extend these results to bacterial growth under environmentally relevant conditions. Our work highlights the power of metabolomics studies in detecting cellular response to growth conditions and the complementarity of NMR and LCMS as omics tools.

65) Wu Z, Cheng Y, Yang Y, Gao Y, Sun X, Wang L, Sun Q, Zhang J, Xu X. In vitro and in vivo anti-Listeria effect of Succinoglycan Riclin through regulating MAPK/IL-6 axis and metabolic profiling. International Journal of Biological Macromolecules (2020)

66) Martín-González MZ, Palacios H, Rodríguez MA, Arola L, Aragonès G, Muguerza B. Beneficial Effects of a Low-dose of Conjugated Linoleic Acid on Body Weight Gain and other Cardiometabolic Risk Factors in Cafeteria Diet-fed Rats. Nutrients (2020)

67) Fan Y, Huang X, Chen J, Han B. Formation of a Mixed-Species Biofilm Is a Survival Strategy for Unculturable Lactic Acid Bacteria and Saccharomyces cerevisiae in Daqu, a Chinese Traditional Fermentation Starter. Front. Microbiol(2020)

68) Abdul Majid ND, Abdul Hamid A, Salleh SZ, et al. Metabolomics approach to investigate the ergogenic effect of Morinda citrifolia L. leaf extract on obese Sprague Dawley rats. Phytochemical Analysis. (2020)

69) Kim SH, Lee W, Kwon D, Lee S, Son SW, Seo MS, Kim KS, Lee YH, Kim S, Jung YS. Metabolomic Analysis of the Liver of a Dextran Sodium Sulfate-Induced Acute Colitis Mouse Model: Implications of the Gut–Liver Connection. Cells (2020)

70) Zhang J, Hang C, Shao W, Li W, Lin D. NMR-Based metabolomic analysis of the anticancer effect of metformin on cholangiocarcinoma cells. (2020)

71) Niemuth J N, Harms C A, Macdonald J M, Stoskopf M K. NMR-based metabolomic profile of cold stun syndrome in loggerhead Caretta caretta, green Chelonia mydas and Kemp's ridley Lepidochelys kempii sea turtles in North Carolina, USA. Wildlife Biology(2020).

72) Chaumont M, Tagliatti V, Channan E M, Colet J M, Bernard A, Morra S, Faoro V. Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial. American Journal of Physiology-Lung Cellular and Molecular Physiology (2020)

73) Yang X, Zhao Y, Sun Q, Yang Y, Gao Y, Ge W, Zhang J. Adenosine accumulation causes metabolic disorders in testes and associates with lower testosterone level in obese mice. Molecular Reproduction and Development. (2020)

74) Azizan A, Xin L A, Hamid A, Ashikin N, Maulidiani M, Mediani A, Abas F. Potentially Bioactive Metabolites from Pineapple Waste Extracts and Their Antioxidant and α-Glucosidase Inhibitory Activities by 1H NMR. Foods (2020)

75) Thøgersen R, Rasmussen M K, Sundekilde U K, Goethals S A, Van Hecke T, Vossen E, Bertram H C. Background Diet Influences TMAO Concentrations Associated with Red Meat Intake without Influencing Apparent Hepatic TMAO-Related Activity in a Porcine Model. Metabolites (2020)

76) Dallons M, Schepkens C, Dupuis A, Tagliatti V, Colet J M. New Insights About Doxorubicin-Induced Toxicity to Cardiomyoblast-Derived H9C2 Cells and Dexrazoxane Cytoprotective Effect: Contribution of In Vitro 1H-NMR Metabonomics. Front. Pharmacol (2020)

77) Ijare O B, Sharpe M A, Baskin D S, Pichumani K. Proton Magnetic Resonance Spectroscopy Characterization of Rathke’s Cleft Cysts (RCCs): Relevance to the Differential Diagnosis of Pituitary Adenomas and RCCs. Cancers (2020)

78) Viswan A, Singh C, Kayastha A M, Azim A, Sinha N. An NMR based panorama of the heterogeneous biology of acute respiratory distress syndrome (ARDS) from the standpoint of metabolic biomarkers. NMR in Biomedicine (2020)

79) Watve S, Barrasso K, Jung S A, Davis K J, Hawver L A, Khataokar A, Ng W L. Parallel quorum-sensing system in Vibrio cholerae prevents signal interference inside the host. PLoS pathogens (2020)

80) Rousseau M. Le rôle des métabolites dérivés de la diète sur la santé cardiométabolique: la contribution des acides aminés à chaîne ramifiée et des polyphénols. (2020)

81) Bingol, K., Masucci, J., & Caldwell, G. NMR-Based Amino acid Assay for Human Plasma and Serum. (2020)

82) Ji Y, Su A, Ma G, Tao T, Fang D, Zhao L, Hu Q. Comparison of bioactive constituents and effects on gut microbiota by in vitro fermentation between Ophicordyceps sinensis and Cordyceps militaris. Journal of Functional Foods (2020)

83) Yin X, Gibbons H, Rundle M, Frost G, McNulty B A, Nugent A P, Brennan L.The Relationship between Fish Intake and Urinary Trimethylamine‐N‐Oxide. Molecular Nutrition & Food Research (2020)

84) Barnett B R, Fathi F, Falco Cobra P, Yi S Y, Anderson J M, Eghbalnia H R, Yu J P J. Metabolic Changes in Synaptosomes in an Animal Model of Schizophrenia Revealed by 1H and 1H, 13C NMR Spectroscopy. Metabolites (2020)

Synaptosomes are isolated nerve terminals that contain synaptic components, including neurotransmitters, metabolites, adhesion/fusion proteins, and nerve terminal receptors. The essential role of synaptosomes in neurotransmission has stimulated keen interest in understanding both their proteomic and metabolic composition. Mass spectrometric (MS) quantification of synaptosomes has illuminated their proteomic composition, but the determination of the metabolic composition by MS has been met with limited success. In this study, we report a proof-of-concept application of one- and two-dimensional nuclear magnetic resonance (NMR) spectroscopy for analyzing the metabolic composition of synaptosomes. We utilize this approach to compare the metabolic composition synaptosomes from a wild-type rat with that from a newly generated genetic rat model (Disc1 svΔ2), which qualitatively recapitulates clinically observed early DISC1 truncations associated with schizophrenia. This study demonstrates the feasibility of using NMR spectroscopy to identify and quantify metabolites within synaptosomal fractions.

85) Brugaletta G, De Cesare A, Zampiga, M., Laghi, L., Oliveri, C., Zhu, C., Sirri, F. Effects of Alternative Administration Programs of a Synbiotic Supplement on Broiler Performance, Foot Pad Dermatitis, Caecal Microbiota, and Blood Metabolites. Animals (2020)

86) Yoon, D., Shin, W. C., Lee, Y. S., Kim, S., Baek, N. I., Lee, D. Y. A Comparative Study on Processed Panax ginseng Products Using HR-MAS NMR-Based Metabolomics. Molecules (2020)

87) Lee, J. S., Kim, S. Y., Chun, Y. S., Chun, Y. J., Shin, S. Y., Choi, C. H., & Choi, H. K. Characteristics of fecal metabolic profiles in patients with irritable bowel syndrome with predominant diarrhea investigated using 1H‐NMR coupled with multivariate statistical analysis. Neurogastroenterology & Motility (2020)

88) Jiang, L., Howlett, K., Patterson, K., & Wang, B. Introduction of a New Method for Two-Dimensional NMR Quantitative Analysis in Metabolomics Studies. Analytical Biochemistry (2020)

89) Murgia, F., Lorefice, L., Poddighe, S., Fenu, G., Secci, M. A., Marrosu, M. G., ... & Atzori, L. Multi-Platform Characterization of Cerebrospinal Fluid and Serum Metabolome of Patients Affected by Relapsing–Remitting and Primary Progressive Multiple Sclerosis. Journal of Clinical Medicine (2020)

Background: Multiple sclerosis (MS) is a chronic immunemediated disease of the central nervous system with a highly variable clinical presentation and disease progression. In this study, we investigate the metabolomics profile of patients affected by relapsing–remitting MS (RRMS)and primary progressive MS (PPMS), in order to find potential biomarkers to distinguish between the two forms. Methods: Cerebrospinal Fluid CSF and blood samples of 34 patients (RRMS n = 22, PPMS n = 12) were collected. Nuclear magnetic resonance (1H-NMR) and mass spectrometry (coupled with a gas chromatography and liquid chromatography) were used as analytical techniques. Subsequently, a multivariate statistical analysis was performed; the resulting significant variables underwent U-Mann–Whitney test and correction for multiple comparisons. Receiver Operating Characteristic ROC curves were built and the pathways analysis was conducted. Results: The analysis of the serum and the CSF of the two classes, allowed the identification of several altered metabolites (lipids, biogenic amines, and amino acids). The pathways analysis indicated the following pathways were affected: Glutathione metabolism, nitrogen metabolism, glutamine–glutamate metabolism, arginine–ornithine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis etc. Conclusion: The analysis allowed the identification of a set of metabolites able to classify RRMS and PPMS patients, each of whom express different patterns of metabolites in the two biofluids.

90) Akhbari, Pouya, et al. "Can joint fluid metabolic profiling (or “metabonomics”) reveal biomarkers for osteoarthritis and inflammatory joint disease? A systematic review." Bone & Joint Research 9.3 (2020)

91) Song, Hye Seon, et al. "Microbial niches in raw ingredients determine microbial community assembly during kimchi fermentation." Food Chemistry (2020)

92) Sehlakgwe, Phophi Freda, Namrita Lall, and Gerhard Prinsloo. "1H-NMR Metabolomics and LC-MS Analysis to Determine Seasonal Variation in a Cosmeceutical Plant Leucosidea sericea." Frontiers in Pharmacology 11 (2020)

93) Gu, Jinping, et al. "Analysis of the Different Metabolic Phenotypes of Metalaxyl Enantiomers in Adolescent Rat by Using 1H NMR Based Urinary Metabolomics." Chemical Research in Toxicology (2020).

94) Graça, Gonçalo, Chung-Ho E. Lau, and Luís G. Gonçalves. "Exploring Cancer Metabolism: Applications of Metabolomics and Metabolic Phenotyping in Cancer Research and Diagnostics." Tumor Microenvironment. Springer, Cham,(2020)

95) Zhang, Guanshi, et al. "Urinary Metabolomics Around Parturition Identifies Metabolite Alterations in Dairy Cows Affected Postpartum by Lameness: Preliminary Study." Dairy 1.1 (2020)

96) Xu, Han, et al. "Therapeutic assessment of fractions of Gastrodiae Rhizoma on chronic atrophic gastritis by 1H NMR-based metabolomics." Journal of Ethnopharmacology (2020)

97) Acevedo-Acevedo, Suehelay, Seneca Cox, and Sean P. Palecek. "Lymphatic endothelial cells (LECs) have minor influence on breast cancer metabolism." The metabolic response of cancer cells to chemotherapeutics and the tumor microenvironment (2020)

98) Acevedo-Acevedo, Suehelay, et al. "Copanlisib (Copan) and ABT263 combination therapy induce changes in colorectal cancer (CRC) metabolism." The metabolic response of cancer cells to chemotherapeutics and the tumor microenvironment (2020)

99) Paul, Anup, et al. "Malignancy prediction among tissues from Oral SCC patients including neck invasions: a 1 H HRMAS NMR based metabolomic study." Metabolomics 16.3 (2020)

100) Garcia-Gutierrez, Enriqueta, et al. "Production of multiple bacteriocins, including the novel bacteriocin gassericin M, by Lactobacillus gasseri LM19, a strain isolated from human milk." Applied Microbiology and Biotechnology (2020)

101) Chandradevan, Machap, et al. "1 H NMR-Based Metabolomics Approach in Investigating the Chemical Profile, Antioxidant and Anti-Inflammatory Activities of Gynura procumbens and Cleome gynandra." Plant Foods for Human Nutrition (2020)

102) Zuo, Jian, et al. "Bioactive fractions from Securidaca inappendiculata alleviated collagen‐induced arthritis in rats by regulating metabolism‐related signaling." The Kaohsiung Journal of Medical Sciences (2020)

103) Pomfret, Sarah M., et al. "Metabolomics for biomonitoring: an evaluation of the metabolome as an indicator of aquatic ecosystem health." Environmental Reviews 28.1 (2020)

104) Acevedo-Acevedo, Suehelay, et al. "Breast cancer influences lymphatic endothelial cell metabolism." The metabolic response of cancer cells to chemotherapeutics and the tumor microenvironment (2020)

105) Yang, Changwei, et al. "Brain-Region Specific Metabolic Abnormalities in Parkinson’s Disease and Levodopa-Induced Dyskinesia." Frontiers in Aging Neuroscience 12 (2020)

106) Stimpson, Scott E., et al. "Human CD8+ T-cells Require Glycolysis to Elicit Effector Function." bioRxiv (2020)

107) Merolle, Lucia, et al. "Heparin‐induced lipoprotein precipitation apheresis in dyslipidemic patients: A multiparametric assessment." Journal of Clinical Apheresis (2020)

108) Anderson, James R., et al. "Ex-Vivo Equine Cartilage Explant Osteoarthritis Model-A Metabolomics and Proteomics Study." bioRxiv (2020)

109) Sylvestre, Duncan A., et al. "Untargeted metabolomic analysis of plasma from relapsing-remitting multiple sclerosis patients reveals changes in metabolites associated with structural changes in brain." Brain Research 1732 (2020)

110) Tiemeier, Gesa L., et al. "Lowering the increased intracellular pH of human‐induced pluripotent stem cell‐derived endothelial cells induces formation of mature Weibel‐Palade bodies." Stem cells translational medicine (2020)

111) Ashraf, Azhaar, et al. "Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis." Redox Biology (2020)

112) Barroso-Batista, João, et al. "Specific eco-evolutionary contexts in the mouse gut reveal Escherichia coli metabolic versatility." Current Biology (2020)

113) Chen, Fang-Hsin, et al. "Multimodal imaging reveals transient liver metabolic disturbance and sinusoidal circulation obstruction after a single administration of ketamine/xylazine mixture." Scientific Reports 10.1 (2020)

114) Sundekilde, Ulrik K., et al. "An Integrated Multi-Omics Analysis Defines Key Pathway Alterations in a Diet-Induced Obesity Mouse Model." Metabolites 10.3 (2020)

115)Hardivillé, Stéphan, et al. "TATA-Box Binding Protein O-GlcNAcylation at T114 Regulates Formation of the B-TFIID Complex and Is Critical for Metabolic Gene Regulation." Molecular Cell 77.5 (2020)

116) Myer, Ciara, et al. "Aqueous humor metabolite profile of psuedoexfoliation glaucoma is distinctive." Molecular Omics (2020)

117) SANTORU, MARIA LAURA. "Study of metabolic alterations in inflammatory bowel diseases." (2020)

118) D’Amato, Alfonsina, et al. "Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity-and neurotransmission-related proteins in young recipients." bioRxiv (2020)

The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems, however, evidence of their direct impact on cognitive functions is still lacking. We tested whether faecal microbiota transplant (FMT) from aged donor mice into young adult recipients affected the hippocampus, an area of the central nervous system (CNS) known to be affected by the ageing process, and related functions.

119) Ahmadi, Shokouh, et al. "Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome/goblet cell/mucin axis." The Journals of Gerontology: Series A (2020)

120) Belivermiş, Murat, et al. "Effects of variable deoxygenation on trace element bioaccumulation and resulting metabolome profiles in the blue mussel (Mytilus edulis)." Chemosphere (2020)

121) Hellal, Khaoula, et al. "Antioxidant, α-Glucosidase, and Nitric Oxide Inhibitory Activities of Six Algerian Traditional Medicinal Plant Extracts and 1H-NMR-Based Metabolomics Study of the Active Extract." Molecules 25.5 (2020)

122) Beachler, T. M., et al. "Plasma metabolomic profiling of healthy pregnant mares and mares with experimentally induced placentitis." Equine Veterinary Journal (2020)

123) Fang-Hsin, Chen, et al. "Multimodal imaging reveals transient liver metabolic disturbance and sinusoidal circulation obstruction after a single administration of ketamine/xylazine mixture." Scientific Reports (Nature Publisher Group) 10.1 (2020)

124) Yi, Shenghui, et al. "NMR-based metabonomic analysis of HUVEC cells during replicative senescence." Aging (Albany NY) 12.4 (2020)

125) Cunha, Camila P., et al. "Metabolic Regulation and Development of Energy Cane Setts upon Auxin Stimulus." Plant and Cell Physiology 61.3 (2020)
Energy cane is a bioenergy crop with an outstanding ability to bud sprouting and increasing yield in ratoon cycles even in marginal lands. Bud fate control is key to biomass production and crop profits due to vegetative propagation and tiller dependency, as well as phenotype plasticity to withstand harsh environmental conditions. During the establishment stage (plant cane cycle), energy cane has a tendency for low root:shoot ratio, which might hamper the ability to cope with stress. Auxin is known to modulate bud sprouting and stimulate rooting in sugarcane. Hence, we treated a slow and a fast bud sprouting energy cane cultivars with auxin or controls (with and without water soaking) for 6 h prior to planting and evaluate plant growth parameters and metabolic profiling using two techniques (gas chromatography with time-of-flight mass spectrometer and nuclear magnetic resonance) to characterize the effect and identify metabolite markers associated with bud inhibition and outgrowth. Auxin inhibited bud burst and promote rooting in setts changing the root:shoot ratio of plantlets. Metabolome allowed the identification of lactate, succinate and aspartate family amino acids as involved in bud fate control through the potential modulation of oxygen and energy status. Investigating environmental and biochemical factors that regulate bud fate can be incremental to other monocot species. Our study provides new insights into bud quiescence and outgrowth in cane hybrids, with the potential to leverage our understanding of yield-related traits, crop establishment and adaptation to global climate change.

126) Hansen, Svend Høime, Ture Damhus, and Jesper Brask. "Rapid and Simple Identification and Quantification of Components in Detergent Formulations by Nuclear Magnetic Resonance Spectroscopy." Journal of Surfactants and Detergents 23.2 (2020)

127) O’Shea, Keiron, and Biswapriya B. Misra. "Software tools, databases and resources in metabolomics: updates from 2018 to 2019." Metabolomics 16.3 (2020)

128) Li, Li, et al. "1H-NMR Metabolomics Analysis of the Effect of Rubusoside on Serum Metabolites of Golden Hamsters on a High-Fat Diet." Molecules 25.6 (2020)

129) Ilhan, Zehra Esra, et al. "Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery." npj Biofilms and Microbiomes 6.1 (2020)

130) Kirkup, Benjamin M., et al. "Antibiotic-induced disturbances of the gut microbiota result in accelerated breast tumour growth via a mast cell-dependent pathway." bioRxiv (2020)

131) Ambeskovic, Mirela, et al. "Ancestral stress programs sex-specific biological aging trajectories and non-communicable disease risk." Aging (Albany NY) 12.4 (2020)

132) Ong, Timothy TX, Ewan W. Blanch, and Oliver AH Jones. "Surface Enhanced Raman Spectroscopy in environmental analysis, monitoring and assessment." Science of The Total Environment (2020)

133) Song, Jiangfeng, et al. "Changes in the sugars, amino acids and organic acids of postharvest spermine-treated immature vegetable soybean (Glycine max L. Merr.) as determined by 1 H NMR spectroscopy." Food Production, Processing and Nutrition 2.1 (2020)

134) Grimaldi, Manuela, et al. "NMR-based metabolomic profile of hypercholesterolemic human sera: Relationship with in vitro gene expression?." Plos one 15.4 (2020)

135) Garwolińska, Dorota, et al. "Nuclear Magnetic Resonance Metabolomics Reveals Qualitative and Quantitative Differences in the Composition of Human Breast Milk and Milk Formulas." Nutrients 12.4 (2020)

136) Komatsu, Yosuke, et al. "Disease progression-associated alterations in fecal metabolites in SAMP1/YitFc mice, a Crohn’s disease model." Metabolomics 16 (2020)

137) Götze, Sandra, et al. "Single and combined effects of the “Deadly trio” hypoxia, hypercapnia and warming on the cellular metabolism of the great scallop Pecten maximus." Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology (2020)

138) Zwierzchowski, Grzegorz, et al. "Milk Metabotyping Identifies Metabolite Alterations in the Whole Raw Milk of Dairy Cows with Lameness." Journal of Agricultural and Food Chemistry (2020).

139) Prideaux, M., et al. "Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/β-catenin signaling pathway." Bone (2020)

140) Ganguly, Sujata, et al. "Nuclear magnetic resonance–based targeted profiling of urinary acetate and citrate following cyclophosphamide therapy in patients with lupus nephritis." Lupus (2020)

141) Muñoz, M., et al. "Nuclear magnetic resonance analysis of female and male pre-hatching embryo metabolites at the embryo-maternal interface." Metabolomics: Official Journal of the Metabolomic Society 16.4 (2020)

142) da Costa, M. B., et al. "Performance, carcass traits and serum metabolomic profile of Nellore males with different genetic potential for post-weaning growth." animal 14.4 (2020)

143) Georgakopoulou, Ioanna, et al. "Metabolic changes in early neonatal life: NMR analysis of the neonatal metabolic profile to monitor postnatal metabolic adaptations." Metabolomics: Official Journal of the Metabolomic Society 16.5 (2020)

144) Chiu, Chih-Yung, et al. "Metabolomic Analysis Reveals Distinct Profiles in the Plasma and Urine Associated with IgE Reactions in Childhood Asthma." Journal of clinical medicine 9.3 (2020)

145) Graham, Stewart F., et al. "Targeted metabolomics highlights perturbed metabolism in the brain of autism spectrum disorder sufferers." IRB 2014 (2020)

146) Darius, Tom, et al. "Influence of different partial pressures of oxygen during continuous hypothermic machine perfusion in a pig kidney ischemia-reperfusion autotransplant model." Transplantation 104.4 (2020)

147) Li, Yun, and Xiu-ju Zhao. "NMR-based plasma metabonomics in hyperlipidemia mice." Analytical Methods (2020)

148) Palacios-Jordan, Héctor, et al. "The Disruption of Liver Metabolic Circadian Rhythms by a Cafeteria Diet Is Sex-Dependent in Fischer 344 Rats." Nutrients 12.4 (2020)

149) Tzimou, Anastasia, et al. "Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats." Biogerontology (2020)

150) Zhu, Chenglin, et al. "An Untargeted Metabolomics Investigation of Jiulong Yak (Bos grunniens) Meat by 1H-NMR." Foods 9.4 (2020)

151) Ramli, Fatin Najwa, et al. "Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats." BioMed Research International 2020 (2020)

152) McNamara, Aoife E., et al. "Metabolomic Based Approach to Identify Biomarkers of Apple Intake." Molecular Nutrition & Food Research (2020)

153) Ji, Chenglong, et al. "Global responses to tris (1-chloro-2-propyl) phosphate (TCPP) in rockfish Sebastes schlegeli using integrated proteomic and metabolomic approach." Science of The Total Environment (2020)

154) Vrieling, Frank, et al. "Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics." Scientific Reports 10.1 (2020)

155) Pongking, Thatsanapong, et al. "A combination of monosodium glutamate and high-fat and high-fructose diets increases the risk of kidney injury, gut dysbiosis and host-microbial co-metabolism." Plos one 15.4 (2020)

156) Palma, Mariana, et al. "Limitations to starch utilization in barramundi (Lates calcarifer) as revealed by NMR-based metabolomics." Frontiers in Physiology 11 (2020)

157) Viana, Laís Rosa, et al. "1H-NMR Based Serum Metabolomics Identifies Different Profile between Sarcopenia and Cancer Cachexia in Ageing Walker 256 Tumour-Bearing Rats." Metabolites 10.4 (2020)

158) Thorstensen, Matt J., et al. "Morphology and Blood Metabolites Reflect Recent Spatial Differences Among Lake Winnipeg Walleye, Sander vitreus." bioRxiv (2020)

159) Shi, Yue, et al. "The effect of polysaccharides from Cibotium barometz on enhancing temozolomide–induced glutathione exhausted in human glioblastoma U87 cells, as revealed by 1H NMR metabolomics analysis." International Journal of Biological Macromolecules (2020)

160) Wojtowicz, Wojciech, et al. "Evaluation of MDA-MB-468 Cell Culture Media Analysis in Predicting Triple-Negative Breast Cancer Patient Sera Metabolic Profiles." Metabolites 10.5 (2020)

161) Zhu, Chenglin, et al. "First Insights into the Urinary Metabolome of Captive Giraffes by Proton Nuclear Magnetic Resonance Spectroscopy." Metabolites 10.4 (2020)

162) Song, Shuang, et al. "Biochar for urban agriculture: Impacts on soil chemical characteristics and on Brassica rapa growth, nutrient content and metabolism over multiple growth cycles." Science of The Total Environment (2020)

163) Beltran, Claudia, et al. "Enhancing Glycolysis Protects against Ischemia-Reperfusion Injury by Reducing ROS Production." Metabolites 10.4 (2020)

164) Roques, Simon, et al. "Integrative Metabolomics for Assessing the Effect of Insect (Hermetia illucens) Protein Extract on Rainbow Trout Metabolism." Metabolites 10.3 (2020)

165) Singh, Vishal, et al. "Vancomycin prevents fermentable fiber-induced liver cancer in mice with dysbiotic gut microbiota." Gut microbes (2020)

166) Griffiths, L. L., et al. "Metabolomic indicators for low-light stress in seagrass." Ecological Indicators 114 (2020)

167) Iliou, Aikaterini, et al. "Malignancy Grade-Dependent Mapping of Metabolic Landscapes in Human Urothelial Bladder Cancer: Identification of Novel, Diagnostic, and Druggable Biomarkers." International journal of molecular sciences 21.5 (2020)

168) Yang, Yanni, et al. "Systems pharmacology reveals the mechanism of activity of Physalis alkekengi L. var. franchetii against lipopolysaccharide‐induced acute lung injury." Journal of Cellular and Molecular Medicine (2020)

169) Kosmopoulou, Mariangela, et al. "Human Melanoma-Cell Metabolic Profiling: Identification of Novel Biomarkers Indicating Metastasis." International Journal of Molecular Sciences 21.7 (2020)

170) Ahmadi, Shokouh, et al. "A human-origin probiotic cocktail ameliorates aging-related leaky gut and inflammation via modulating microbiota-taurine-tight junction axis." JCI insight (2020)

171) Lee, Hyun-Wook, et al. "NBCe1-A is required for the renal ammonia and K+ response to hypokalemia." American Journal of Physiology-Renal Physiology 318.2 (2020)

172) Lee, Hyun-Wook, et al. "NBCe1-A is required for the renal ammonia and K+ response to hypokalemia." American journal of physiology. Renal physiology 318.2 (2020)

173) Datir, Sagar S., et al. "Cold storage reveals distinct metabolic perturbations in processing and non-processing cultivars of potato (Solanum tuberosum L.)." Scientific reports 10.1 (2020)

174) Anderson, James R., et al. "Optimisation of Synovial Fluid Collection and Processing for NMR Metabolomics and LC-MS/MS Proteomics." Journal of Proteome Research (2020)

175) Bawadikji, Abdulkader Ahmad, et al. "Plasma metabolites as predictors of warfarin outcome in atrial fibrillation." American Journal of Cardiovascular Drugs 20.2 (2020)

176) Jakobsen, Louise, et al. "Metabolic Effects of Bovine Milk Oligosaccharides on Selected Commensals of the Infant Microbiome—Commensalism and Postbiotic Effects." Metabolites 10.4 (2020)

177) Cibecchini, Giulia, et al. "Anti-angiogenic effect of graphene oxide in primary human endothelial cells." ACS Applied Materials & Interfaces (2020)

178) Xyda, Souzana-Eirini, et al. "Distinct influence of omega-3 fatty acids on the plasma metabolome of healthy older adults." The Journals of Gerontology: Series A 75.5 (2020)

179) Noor, Halimatul Saadiah Mohammad, et al. "Urinary Metabolomics and Biochemical Analysis of Antihyperglycemic Effect of Ficus deltoidea Jack Varieties in Streptozotocin-Nicotinamide–Induced Diabetic Rats." Applied Biochemistry and Biotechnology (2020)

180) Wang, Qian, et al. "The biochemical and metabolic profiles of dairy cows with mycotoxins-contaminated diets." PeerJ 8 (2020)

181) Ramsey, John S., et al. "Longitudinal transcriptomic, proteomic, and metabolomic analysis of Citrus limon response to graft inoculation by ‘Candidatus Liberibacter asiaticus’." Journal of Proteome Research (2020)

182) Verhoeven, Aswin, Martin Giera, and Oleg A. Mayboroda. "Scientific workflow managers in metabolomics: an overview." Analyst (2020)

183) Huot, Joshua R., et al. "Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia." JCI insight (2020)

184) Leenders, Justine, et al. "Benchtop Low-Frequency 60 MHz NMR Analysis of Urine: A Comparative Metabolomics Investigation." Metabolites 10.4 (2020)

185) Ong, Timothy TX, Ewan W. Blanch, and Oliver AH Jones. "Surface Enhanced Raman Spectroscopy in environmental analysis, monitoring and assessment." Science of The Total Environment (2020)

186) Perduca, Massimiliano, et al. "Structure and properties of the oyster mushroom (Pleurotus ostreatus) lectin." Glycobiology (2020)

187) Pilona, Alan C., et al. "METABOLÔMICA DE PLANTAS: MÉTODOS E DESAFIOS." (2020)

188) Pires, Bárbara Aliende. "Integração de ômicas para a investigação de mecanismos de resistência de" Moniliophthora perniciosa" a um fungicida inibidor da enzima oxidase alternativa." (2020)

189) Kandasamy, Sujatha, et al. "1H HRMAS-NMR based metabolic fingerprints for discrimination of cheeses based on sensory qualities." Saudi Journal of Biological Sciences 27.6 (2020)

190) Azam, Amalina Ahmad, et al. "¹H NMR-Based Metabolomics of Clinacanthus nutans Leaves Extracts in Correlation with Their Anti-neuroinflammation Towards LPS-Induced BV2 Cells." Records of Natural Products 14.4 (2020)

191) Takahashi, Yuta, et al. "Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection." Translational psychiatry 10.1 (2020)

192) Saadouli, Ilhem, et al. "Isolation, Characterization and Chemical Synthesis of Large Spectrum Antimicrobial Cyclic Dipeptide (l-leu-l-pro) from Streptomyces misionensisV16R3Y1 Bacteria Extracts. A Novel 1H NMR Metabolomic Approach." Antibiotics 9.5 (2020)

193) Smercina, Darian N., et al. "Switchgrass Rhizosphere Metabolite Chemistry Driven by Nitrogen Availability." Phytobiomes Journal (2020)

194) Jayawardhane, Jayamini, et al. "Roles for Plant Mitochondrial Alternative Oxidase Under Normoxia, Hypoxia, and Reoxygenation Conditions." Frontiers in Plant Science 11 (2020)

195) Charris-Molina, Andrés, et al. "Consecutive Queries to Assess Biological Correlation in NMR Metabolomics: Performance of Comprehensive Search of Multiplets over Typical 1D 1H NMR Database Search." Journal of Proteome Research (2020)

196) Mielko, Karolina Anna, et al. "Possible metabolic switch between environmental and pathogenic Pseudomonas aeruginosa strains: 1H NMR based metabolomics study." Journal of Pharmaceutical and Biomedical Analysis (2020)

197) Gomes, A., et al. "Berry fruits modulate kidney dysfunction and urine metabolome in Dahl salt-sensitive rats." Free Radical Biology and Medicine (2020)

198) Upadhyay, Deepti, et al. "Abnormalities in metabolic pathways in celiac disease investigated by the metabolic profiling of small intestinal mucosa, blood plasma and urine by NMR spectroscopy." NMR in Biomedicine (2020)

199) Yu, Deliang, et al. "Metal pollution and its biological effects in swimming crab Portunus trituberculatus by NMR-based metabolomics." Marine Pollution Bulletin 157 (2020)

200) Kim, Hyun Sang, et al. "Research fecal metabolite according to fed different ratios of roughage to concentrate on lactating cow using 1 H-NMR analysis." Journal of the Korea Academia-Industrial cooperation Society 21.2 (2020)

201) Bliziotis, Nikolaos G., et al. "A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics." Metabolomics 16.5 (2020)

202) Abdul-Hamid, Nur Ashikin, et al. "Quality evaluation of the physical properties, phytochemicals, biological activities and proximate analysis of nine Saudi date palm fruit varieties." Journal of the Saudi Society of Agricultural Sciences 19.2 (2020)

203) Jin, Zekun, et al. "Inhibition of Bacillus cereus by garlic (Allium sativum) essential oil during manufacture of white sufu, a traditional Chinese fermented soybean curd." LWT (2020)

204) Srikanth, Krishnamoorthy, et al. "Genome-Wide Transcriptome and Metabolome Analyses Provide Novel Insights and Suggest a Sex-Specific Response to Heat Stress in Pigs." Genes 11.5 (2020)

205) Bislev, Lise Sofie, et al. "Circulating Levels of Muscle-Related Metabolites Increase in Response to a Daily Moderately High Dose of a Vitamin D3 Supplement in Women with Vitamin D Insufficiency—Secondary Analysis of a Randomized Placebo-Controlled Trial." Nutrients 12.5 (2020)

206) Li, Yan Jun, et al. "Dietary Fiber Protects against Diabetic Nephropathy through Short-Chain Fatty Acid–Mediated Activation of G Protein–Coupled Receptors GPR43 and GPR109A." Journal of the American Society of Nephrology 31.6 (2020)

207) Tzimou, Anastasia, et al. "Effects of lifelong exercise and aging on the blood metabolic fingerprint of rats." Biogerontology (2020)

208) Ramli, Fatin Najwa, et al. "Effect of Saffron Extract and Crocin in Serum Metabolites of Induced Obesity Rats." BioMed Research International 2020 (2020)

209) 권소이. Urine myo-inositol, the novel prognostic biomarker for diabetic kidney disease. Diss. 서울대학교 대학원, (2020)

210) Dekker, Shosha EI, et al. "Urinary metabolites associate with the rate of kidney function decline in patients with autosomal dominant polycystic kidney disease." Plos one 15.5 (2020)

211) Mofokeng, Motiki M., et al. "Yield and Metabolite Production of Pelargonium sidoides DC. in Response to Irrigation and Nitrogen Management." Metabolites 10.6 (2020)

212) Baptista, Aline L., et al. "Potential biomarkers of the Turnover, Mineralization and Volume classification: results using NMR‐metabolomics in hemodialysis patients." JBMR Plus. (2020)

213) Zhang, Tong, et al. "NMR-based metabolomic analysis for the effects of Huiyang Shengji extract on rat diabetic skin ulcers." Journal of Ethnopharmacology (2020)

214) Frank, Vrieling, et al. "Analyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics." Scientific Reports (Nature Publisher Group) 10.1 (2020)

215) Abd Ghafar, Siti Zulaikha, et al. "Complementary NMR-and MS-Based Metabolomics Approaches Reveal the Correlations of Phytochemicals and Biological Activities in Phyllanthus acidus Leaf Extracts." Food Research International (2020)

216) Graham, R. J. T. Y., et al. "Metabolomic analysis of synovial fluid from Thoroughbred racehorses diagnosed with palmar osteochondral disease using magnetic resonance imaging." Equine Veterinary Journal 52.3 (2020)

217) Zannoni, Augusta, et al. "Non-invasive assessment of fecal stress biomarkers in hunting dogs during exercise and at rest." Frontiers in Veterinary Science 7 (2020)

218) Anzian, Aliaa, et al. "Antibacterial Activity and Metabolomics Profiling of Torch Ginger (Etlingera elatior Jack) Flower Oil Extracted Using Subcritical Carbon Dioxide (CO2)." Evidence-Based Complementary and Alternative Medicine 2020 (2020)

219) Liang, Heng-Yu, et al. "Effects of Saccharomyces Cerevisiae Strains on Chemical Profiles of Cabernet Sauvignon Wines: Based on the Combined Results of [. sup. 1] H NMR, HS-SPME/GC-MS and HPLC-DAD-ESI-MS/MS." Current Topics in Nutraceutical Research 18.2 (2020)

220) Santoru, Maria Laura, et al. "Modulatory Effect of Nicotinic Acid on the Metabolism of Caco-2 Cells Exposed to IL-1β and LPS." Metabolites 10.5 (2020)

221) Cai, Aimin, et al. "Synergism between SLC6A14 blockade and gemcitabine in pancreactic cancer: a 1H-NMR-based metabolomic study in pancreatic cancer cells." Biochemical Journal 477.10 (2020)

222) Dutta, Prasanta, et al. "Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy." International Journal of Molecular Sciences 21.10 (2020)

223) Akyol, Sumeyya, et al. "Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies." Brain Research (2020)

224) Luo, Huai-Zhi, et al. "Growth inhibition and metabolomic analysis of Xanthomonas oryzae pv. oryzae treated with resveratrol." BMC microbiology 20 (2020)

225) Dudka, Ilona, et al. "Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status." BMC cancer 20 (2020)

226) Ge, Wenhao, et al. "Decreased T-cell mediated hepatic injury in concanavalin A-treated PLRP2-deficient mice." International Immunopharmacology 85 (2020)

227) Aznar-Alemany, Òscar, and Marta Llorca. "Metabolomics strategies and analytical techniques for the investigation of contaminants of industrial origin." Environmental Metabolomics. Elsevier (2020)

228) Jothi, Jayalakshmi, Arambakkam Janardhanam Vanisree, and Rama Krishnaswamy. "METABOLIC VARIATIONS AMONG LOW GRADE AND HIGH GRADE GLIOMAS–PROFILING BY 1H NMR SPECTROSCOPY." Journal of Proteome Research (2020)

229) Barbieri, Federica, et al. "Metabolism of Lactobacillus sakei Chr82 in the Presence of Different Amounts of Fermentable Sugars." Foods 9.6 (2020)

230) Damerau, Annelie, et al. "Evaluation of the composition and oxidative status of omega-3 fatty acid supplements on the Finnish market using NMR and SPME-GC-MS in comparison with conventional methods." Food Chemistry (2020)

231) Rocha, Jéssica R. da, et al. "EVALUATION OF THE METABOLIC PRODUCTION OF THE ENDOPHYTIC FUNGUS Phomopsis sp." Química Nova 43.3 (2020)

232) Abinandan, Sudharsanam, et al. "Acid-adapted microalgae exhibit phenotypic changes for their survival in acid mine drainage samples." FEMS Microbiology Ecology (2020)

233) Xu, Dingqiao, et al. "NMR-based metabolomics approach revels effects of antioxidant nutrients in sepsis-induced changes in rats liver injury." The Journal of Nutritional Biochemistry (2020)

234) Gebreab, Kiflom Y., et al. "Comparative toxicometabolomics of perfluorooctanoic acid (PFOA) and next-generation perfluoroalkyl substances." Environmental Pollution (2020)

235) Luo, Li, et al. "miR-125a-5p inhibits glycolysis by targeting hexokinase-II to improve pulmonary arterial hypertension." Aging 12.10 (2020)

236) Luke, Timothy DW, et al. "Use of Large and Diverse Datasets for 1H NMR Serum Metabolic Profiling of Early Lactation Dairy Cows." Metabolites 10.5 (2020)

237) Warren, Emily B., et al. "Manganese-induced mitochondrial dysfunction is not detectable at exposures below the acute cytotoxic threshold in neuronal cell types." Toxicological Sciences (2020)

238) Cha, Kwang Hyun, et al. "A low dose of beryllium exposure influences gut microbiota and promotes metabolic syndrome." (2020)

239) Dallons, Matthieu, et al. "A Comparative Study of Rat Urine 1H-NMR Metabolome Changes Presumably Arising from Isoproterenol-Induced Heart Necrosis Versus Clarithromycin-Induced QT Interval Prolongation." Biology 9.5 (2020)

240) Ray, Pratikshya, Uday Pandey, and Palok Aich. "Comparative analysis of beneficial effects of Vancomycin treatment on Th1-and Th2-biased mice and role of gut microbiota." bioRxiv (2020)

241) Püngel, Deborah, et al. "Bifidobacterium breve UCC2003 Exopolysaccharide Modulates the Early Life Microbiota by Acting as a Potential Dietary Substrate." Nutrients 12.4 (2020)

242) Kistner, Sina, et al. "An NMR-Based Approach to Identify Urinary Metabolites Associated with Acute Physical Exercise and Cardiorespiratory Fitness in Healthy Humans—Results of the KarMeN Study." Metabolites 10.5 (2020)

243) Ferlizza, E., et al. "Urinary proteome and metabolome in dogs (Canis lupus familiaris): The effect of chronic kidney disease." Journal of Proteomics (2020)

244) Lanctôt, Chantal M., et al. "Physiological stress response of the scleractinian coral Stylophora pistillata exposed to polyethylene microplastics." Environmental Pollution (2020)

245) Bajic, Danica, et al. "Gut microbiota derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice." Journal of Crohn's and Colitis (2020)

246) Schadewijk, R. van. "Microcoil MRI of plants and algae at ultra-high field: an exploration of metabolic imaging." Scientific Reports (2020)

247) Ďurišová, Kamila, et al. "Functional dissection of γ-aminobutyric acid metabolism in Neurospora crassa." Gen. Physiol. Biophys 39 (2020)

248) Hughes, Kevin R., et al. "The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding." The FASEB Journal 34.5 (2020)

249) Cistola, David P., and Michelle Robinson. "Methods for monitoring changes in the core of lipoprotein particles in metabolism and disease." (2020)

250) Wang, Mengyuan, et al. "A knowledge-driven network-based analytical framework for the identification of rumen metabolites." IEEE Transactions on NanoBioscience (2020).

251) Isha, Azizul, et al. "NMR-based metabolomics reveals effect of Ganoderma boninense infection on oil palm leaf at 30 days post-infection."(2020)

252) Bykowski, Elani Ann. Urinary and blood-derived biomarkers indicative of recovery from traumatic brain injury and spinal cord injury. Diss. Lethbridge, Alta.: University of Lethbridge, Department of Neuroscience (2020)

253) Pritchard-Oh, Alexander. Understanding the Sf9–Baculovirus Expression Vector System: Exploring the Metabolic Basis of the Cell Density Effect through Nuclear Magnetic Resonance Spectroscopy and Flow Cytometry Analysis of Fluorescent Protein Accumulation. MS thesis. University of Waterloo (2020)

254) Soumoy, Laura, et al. "Metabolic Reprogramming in Metastatic Melanoma with Acquired Resistance to Targeted Therapies: Integrative Metabolomic and Proteomic Analysis." Cancers 12.5 (2020)

255) Anderson, James R., et al. "Metabolomic and Proteomic Stratification of Equine Osteoarthritis." bioRxiv (2020)

256) Ding, Yi, et al. "Tuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae." bioRxiv (2020)

257) Gloaguen, Yoann, et al. "Machine learning-based classification to improve Gas Chromatography-Mass spectrometry data processing." European RFMF Metabomeeting (2020)

258) Monnerie, Stéphanie, et al. "INPUT OF DEEP PHENOTYPING IN THE METABOLIC SYNDROME STRATIFICATION." European RFMF Metabomeeting (2020)

259) Bilhorn, Cora. "Amount and Sources of Population Variability in the Metabolome of a Crayfish Species." (2020).

260) Giacomelli, Elisa, et al. "Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease." Cell Stem Cell (2020)

261) Ostermann, Michael Rothe, et al. "MS-based targeted metabolomics of eicosanoids and other oxylipins: Analytical variability and interlaboratory comparison of esterified oxylipin profile." (2020)

262) Peacock III, James Clayton, et al. "Magnetic resonance spectroscopy pulse sequence, acquisition, and processing system and method." (2020)

263) Scalabrin, Mattia. Redox regulation of mitochondrial responses in denervated and ageing skeletal muscle. Diss. University of Liverpool (2020)

264) Fu, Ze-Lin, et al. "Metabolomic study of disease progression in scrapie prion infected mice; validation of a novel method for brain metabolite extraction." Metabolomics 16.6 (2020)

265) Addie, Ruben D., et al. "Metabolic reprogramming related to whole-chromosome instability in models for Hürthle cell carcinoma." Scientific Reports 10.1 (2020)

266) Lau, Hazel, Anna Karen Carrasco Laserna, and Sam Fong Yau Li. "1H NMR-based metabolomics for the discrimination of celery (Apium graveolens L. var. dulce) from different geographical origins." Food Chemistry (2020)

267) Nizioł, Joanna, et al. "Nuclear magnetic resonance and surface-assisted laser desorption/ionization mass spectrometry-based serum metabolomics of kidney cancer." Analytical and Bioanalytical Chemistry (2020)

268) Wilkop, Thomas E., et al. "NMR spectroscopy analysis reveals an altered metabolic homeostasis in Arabidopsis seedlings treated with a cytokinesis inhibitor." bioRxiv (2020)

269) Eom, Jun Sik, et al. "Metabolomics comparison of rumen fluid and milk in dairy cattle using proton nuclear magnetic resonance spectroscopy." Asian-Australasian Journal of Animal Sciences (2020)

270) Giera, Martin, and Hans Morreau. "Metabolic reprogramming related to whole-chromosome instability in models for Hürthle cell carcinoma." (2020)

271) Cônsolo, Nara RB, et al. "Investigation of metabolites associated with confinement odour in chilled vacuum-packed lamb by proton nuclear magnetic resonance (1H NMR) spectroscopy." Meat Science (2020)

272) Tarrant, Julie, et al. "Gut dysbiosis modulates the immune response to factor VIII in murine hemophilia A." Blood advances 4.12 (2020)

273) Xiong, Tao, et al. "Metabolic profiles of Oncomelania hupensis after molluscicidal treatment: carbohydrate metabolism targeted and energy deficiency." Acta Tropica (2020)

274) Antonelo, Daniel, et al. "Metabolites and Metabolic Pathways Correlated With Beef Tenderness." Meat and Muscle Biology 4.1 (2020)

275) Klimczak, Leszek J., et al. "Mixture analyses of air-sampled pollen extracts can accurately differentiate pollen taxa." Atmospheric Environment (2020)

276) Muhammed, Hafis, et al. "Metabolomics analysis revealed significantly higher synovial Phe/Tyr ratio in reactive arthritis and undifferentiated spondyloarthropathy." Rheumatology 59.7 (2020)

277) Maki, Katherine Anne, et al. "Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats." Physiological Genomics (2020)

278) Chiu, Chih‐Yung, et al. "Integration of metagenomics‐metabolomics reveals specific signatures and functions of airway microbiota in mite‐sensitized childhood asthma." Allergy (2020)

279) Zhang, Tingting, et al. "NMR-based metabolomics characterizes metabolic changes in different brain regions of streptozotocin-induced diabetic mice with cognitive decline." Metabolic Brain Disease (2020)

280) Pereira, Giuliano Elias, et al. "Trunk girdling increased stomatal conductance in Cabernet Sauvignon Grapevines, reduced glutamine, and increased malvidin-3-glucoside and quercetin-3-glucoside concentrations in skins and pulp at harvest." Embrapa Uva e Vinho-Artigo em periódico indexado (ALICE) (2020)

281) Lalaleo, Liliana, et al. "Differentiating, evaluating, and classifying three quinoa ecotypes by washing, cooking and germination treatments, using 1H NMR-based metabolomic approach." Food Chemistry (2020)

282) Nilsson, Anders K., et al. "Serum choline in extremely preterm infants declines with increasing parenteral nutrition." European Journal of Nutrition (2020)

283) Jeong, Jin Young, et al. "Nuclear magnetic resonance-based metabolomics analysis and characteristics of beef in different fattening periods." Journal of Animal Science and Technology 62.3 (2020)

284) Han, Dong Min, et al. "Dynamics of microbial communities and metabolites in ganjang, a traditional Korean fermented soy sauce, during fermentation." Food Microbiology (2020)

285) Yilmaz, Ali, et al. "Metabolic profiling of CSF from people suffering from Sporadic and LRRK2 Parkinson’s disease: a pilot study." (2020)

286) Oh, Junsang, et al. "Efficacy of Ethyl Acetate Fraction of Cordyceps militaris for Cancer-Related Fatigue in Blood Biochemical and 1H-Nuclear Magnetic Resonance Metabolomic Analyses." Integrative cancer therapies 19 (2020)

287) Pauzi, Fatin Athirah, et al. "Exploring Metabolic Signature of Protein Energy Wasting in Hemodialysis Patients." Metabolites 10.7 (2020)

288) Hao, Desirée, et al. "Metabolites as Prognostic Markers for Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients Treated with First-Line Platinum-Doublet Chemotherapy." Cancers 12.7 (2020)

289) Thøgersen, Rebekka, et al. "Inulin and milk mineral fortification of a pork sausage exhibits distinct effects on the microbiome and biochemical activity in the gut of healthy rats." Food Chemistry (2020)

290) Kronschnabel, Alessandra. Tenacity of the Antarctic limpet Nacella concinna after long-term acclimation to warming. Diss. University of Rostock, (2020)

291) Luangwilai, Mayuree, et al. "Comparative metabolite profiling of raw milk from subclinical and clinical mastitis cows using 1H‐NMR combined with chemometric analysis." International Journal of Food Science & Technology (2020)

292) Maignien, Chloé, et al. "Endometriosis Phenotypes Are Associated With Specific Serum Metabolic Profiles Determined By Proton-Nuclear Magnetic Resonance." Reproductive BioMedicine Online (2020)

293) Cui, Mengni, et al. "Human faecal 1H-NMR metabolomics: Evaluation of solvent and sample processing on coverage and reproducibility of signature metabolites." Analytical Chemistry (2020)

294) Yu, Yuanrui, et al. "Effect of natural spices on precursor substances and volatile flavor compounds of boiled Wuding chicken during processing." Flavour and Fragrance Journal (2020)

295) Haak, Bastiaan W., et al. "Altered Patterns of Compositional and Functional Disruption of the Gut Microbiota in Typhoid Fever and Nontyphoidal Febrile Illness." Open Forum Infectious Diseases. Vol. 7. No. 7. US: Oxford University Press, (2020)

296) Carrola, Joana, et al. "Macrophage metabolomics reveals differential metabolic responses to subtoxic levels of silver nanoparticles and ionic silver." European Journal of Inorganic Chemistry 2020.19 (2020)

297) Han, Bin, et al. "NMR-Based Metabonomic Study Reveals Intervention Effects of Polydatin on Potassium Oxonate-Induced Hyperuricemia in Rats." Oxidative Medicine and Cellular Longevity 2020 (2020)

298) Schnelle, Moritz, et al. "In vivo [U-13C]-glucose labeling to assess heart metabolism in murine models of pressure and volume overload." American Journal of Physiology-Heart and Circulatory Physiology (2020)

299) Gómez, Enrique, et al. "METABOLOMIC PROFILING OF BOS TAURUS BEEF, DAIRY AND CROSSBRED CATTLE: A BETWEEN-BREEDS META-ANALYSIS." Journal of Agricultural and Food Chemistry (2020).

300) Wang, Gangqi, et al. "Shear stress regulation of endothelial glycocalyx structure is determined by glucobiosynthesis." Arteriosclerosis, Thrombosis, and Vascular Biology 40.2 (2020)

301) Muhialdin, Belal J., et al. "Metabolomics profiling and antibacterial activity of fermented ginger paste extends the shelf life of chicken meat." LWT (2020)

302) Miyaguti, Natália Angelo da Silva, et al. "Serum and Muscle 1H NMR-Based Metabolomics Profiles Reveal Metabolic Changes Influenced by a Maternal Leucine-Rich Diet in Tumor-Bearing Adult Offspring Rats." Nutrients 12.7 (2020)

303) Ma, Seohee, et al. "Vibrio harveyi Infection Significantly Alters Amino Acid and Carbohydrate Metabolism in Whiteleg Shrimp, Litopenaeus vannamei." Metabolites 10.6 (2020)

304) Жгун, Е. С., et al. "Оценка уровня метаболитов в фекалиях пациентов с воспалительными заболеваниями кишечника." Биомедицинская химия 66.3 (2020)

305) Long, Dani M., et al. "Lactate dehydrogenase expression modulates longevity and neurodegeneration in Drosophila melanogaster." Aging (Albany NY) 12.11 (2020)

306) He, Shanshan, et al. "1H-NMR-based metabolomic study of the effects of flavonoids on citrinin production by Monascus." Food Research International (2020)

307) Saleh, Mohammed SM, et al. "Modulation of metabolic alterations of obese diabetic rats upon treatment with Salacca zalacca fruits extract using 1H NMR-based metabolomics." Food Research International (2020)

308) Mor, Natalia Cristina, et al. "A Protocol for Fish Lipid Analysis Using Nuclear Magnetic Resonance Spectroscopy." Journal of the Brazilian Chemical Society 31.4 (2020)

309) Liang, Kung-Hao, et al. "Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study." Scientific Reports 10.1 (2020)

310) 蔦瑞樹, et al. "切らずに測る野菜の鮮度." 人工知能学会全国大会論文集 第 34 回全国大会 (2020). 一般社団法人 人工知能学会, (2020)

311) Mohd Roby, Bizura Hasida, et al. "Physical properties, storage stability, and consumer acceptability for sourdough bread produced using encapsulated kombucha sourdough starter culture." Journal of Food Science (2020)

312) Mili, Manhal, et al. "Fast and ergonomic extraction of adherent mammalian cells for NMR-based metabolomics studies." Analytical and Bioanalytical Chemistry (2020)

313) Lee, Wei-Hua, et al. "Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene." Experimental Biology and Medicine (2020)

314) Ji, Chenyang, et al. "Four cypermethrin isomers induced stereoselective metabolism in H295R cells." Chirality (2020)

315) Gómez, Enrique, et al. "Metabolomic identification of pregnancy-specific biomarkers in blood plasma of BOS TAURUS beef cattle after transfer of in vitro produced embryos." Journal of proteomics (2020)

316) Ahlborn, Natalie, et al. "In Vitro Fermentation of Sheep and Cow Milk Using Infant Fecal Bacteria." Nutrients 12.6 (2020)

317) Ruberti, Olívia Moraes, et al. "Aerobic training prevents cardiometabolic changes triggered by myocardial infarction in ovariectomized rats." Journal of Cellular Physiology (2020)

318) Garcia-Perez, Isabel, et al. "Identifying unknown metabolites using NMR-based metabolic profiling techniques." Nature Protocols (2020)

319) Ouattara, Djomangan Adama, et al. "An integrated transcriptomics and metabolomics study of the immune response of newly hatched chicks to the cytosine-phosphate-guanine oligonucleotide stimulation." Poultry Science (2020)

320) Bazzano, Marilena, et al. "Respiratory metabolites in bronchoalveolar lavage fluid (BALF) and exhaled breath condensate (EBC) can differentiate horses affected by severe equine asthma from healthy horses." BMC Veterinary Research 16.1 (2020)

321) Dai, Li‐shang, et al. "1H‐NMR‐based metabonomic evaluation of pesticides camptothecin and matrine against larvae of Spodoptera litura." Pest Management Science (2020)

322) Whitehead, Michelle C., et al. "Biochemical Effects of Routine Gonadectomy on Blood of Domestic Ferrets (Mustela putorius furo)." Journal of the American Association for Laboratory Animal Science (2020)

323) Kung-Hao, Liang, et al. "Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study." Scientific Reports (Nature Publisher Group) 10.1 (2020)

324) Sulaiman, Fadzil, et al. "Metabolite Profiles of Red and Yellow Watermelon (Citrullus lanatus) Cultivars Using a 1H-NMR Metabolomics Approach." Molecules 25.14 (2020)

325) Thorstensen, Matt J., et al. "Morphology and blood metabolites reflect recent spatial and temporal differences among Lake Winnipeg walleye, Sander vitreus." Journal of Great Lakes Research (2020)

326) Zheng, Jiamin, et al. "A Comprehensive Targeted Metabolomic Assay for Urine Analysis." Analytical Chemistry (2020)

327) Luke, Timothy DW, et al. "A Tale of Two Biomarkers: Untargeted 1H NMR Metabolomic Fingerprinting of BHBA and NEFA in Early Lactation Dairy Cows." Metabolites 10.6 (2020)

328) Albrecht, Benjamin, et al. "Pursuing experimental reproducibility: an efficient protocol for the preparation of cerebrospinal fluid samples for NMR-based metabolomics and analysis of sample degradation." Metabolites 10.6 (2020)

329) Gutiérrez, Tomás, et al. "The ER chaperone calnexin controls mitochondrial positioning and respiration." Science Signaling 13.638 (2020)

330) Quiroga, Rocío, et al. "Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children." Experimental & Molecular Medicine (2020)

331) Tozzi, Francesca, et al. "Morphological and nutraceutical characterization of six pomegranate cultivars of global commercial interest." Scientia Horticulturae 272 (2020)

332) Lee, Sujin, et al. "The effects of Mozart's music on metabolic response upon stress." Journal of the Korean Magnetic Resonance Society 24.1 (2020)

333) Cruz, Bread, et al. "Leucine-Rich Diet Modulates the Metabolomic and Proteomic Profile of Skeletal Muscle during Cancer Cachexia." Cancers 12.7 (2020)

334) Magri, Agnes, et al. "Production of fructooligosaccharides by Bacillus subtilis natto CCT7712 and their antiproliferative potential." Journal of applied microbiology 128.5 (2020)

335) Hassanzadeh Keshteli, Ammar. "Diet and inflammatory bowel disease; a metabolomic approach." (2020)

336) Haak, Bastiaan W., et al. "Intestinal transkingdom analysis on the impact of antibiotic perturbation in health and critical illness." bioRxiv (2020)

337) Sinton, Matthew C., et al. "Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation." BioRxiv (2020)

338) Baranovicova, Eva, et al. "Time‐related metabolomics study in the rat plasma after global cerebral ischemia and reperfusion: Effect of ischemic preconditioning." IUBMB life (2020)

339) Ragone, Rosa, et al. "Development of a food class-discrimination system by non-targeted NMR analyses using different magnetic field strengths." Food Chemistry (2020)

340) Sadhasivam, Senthilkumar. "Effects of an 8-day advanced meditation, Samyama On physical, psychological and spiritual wellbeing, And associated neural mechanisms." (2020)

341) Foroutan, Aidin, et al. "The Bovine Metabolome." Metabolites 10.6 (2020)

342) Lalwani, Ashna M., et al. "The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease." Metabolites 10.6 (2020)

343) Gonzalez-Franquesa, Alba, et al. "Obesity causes irreversible mitochondria failure in visceral adipose tissue despite successful anti-obesogenic lifestyle-based interventions." bioRxiv (2020)

344) Pausan, Manuela-Raluca, et al. "Human Milk Oligosaccharides Modulate the Risk for Preterm Birth in a Microbiome-Dependent and-Independent Manner." Msystems 5.3 (2020)

345) Pilon, Alan C., et al. "PLANT METABOLOMICS: METHODS AND CHALLENGES." Química Nova 43.3 (2020)

346) Moreno, Vanessa. "Utility of the “omics” in kidney disease: Methods of analysis, sampling considerations, and technical approaches in renal biomarkers." Kidney Biomarkers. Academic Press, (2020)

347) Zhang, Wencheng, et al. "Patch Grafting of Cells into Solid Organs Such as Liver and Pancreas." (2020)

348) Piras, Cristina, et al. "Urinary 1H-NMR Metabolic Signature in Subjects Undergoing Colonoscopy for Colon Cancer Diagnosis." Applied Sciences 10.16 (2020)

349) Cônsolo, Nara RB, et al. "Characterization of chicken muscle disorders through metabolomics, pathway analysis, and water relaxometry: a pilot study." Poultry Science (2020)

350) Chen, Kang, et al. "Effects of anthocyanin extracts from bilberry (Vaccinium myrtillus) and purple potato (Solanum tuberosum var.‘Synkeä Sakari’) on plasma metabolomics profile of obese diabetic Zucker rats." Journal of Agricultural and Food Chemistry (2020)

351) Stockwell, Marc, Ian Goodall, and Dušan Uhrín. "Quantification of whisky congeners by 1H NMR spectroscopy." Analytical Science Advances. (2020)

352) Kurek, Itzhak, and Robert Mckee. "Method and Systems for detection of biomarkers in response to intoxicant consumption." U.S. Patent Application No. 15/973,459. (2020)

353) Muhialdin, Belal J., Hana Kadum, and Anis Shobirin Meor Hussin. "Metabolomics profiling of fermented cantaloupe juice and the potential application to extend the shelf life of fresh cantaloupe juice for six months at 8° C." Food Control (2020)

354) Banoei, Mohammad M., et al. "Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)." Critical Care 24.1 (2020)

355) Poplawski, Janet, et al. "Cardiorenal metabolic biomarkers link early life stress to risk of non-communicable diseases and adverse mental health outcomes." Scientific RepoRtS 10.1 (2020)

356) Aries, Michelle L., and Mary J. Cloninger. "NMR metabolomic analysis of bacterial resistance pathways using multivalent quaternary ammonium functionalized macromolecules." Metabolomics 16.8 (2020)

357) Komatsu, Yosuke, et al. "1 H NMR metabolomic and transcriptomic analyses reveal urinary metabolites as biomarker candidates in response to protein undernutrition in adult rats." British Journal of Nutrition: 1-31.(2020)

358) Montoya-Arroyo, Alexander, et al. "Oral administration of Costa Rican guava (Psidium friedrichsthalianum) juice induces changes in urinary excretion of energy-related compounds in Wistar rats determined by 1H NMR." NFS Journal (2020)

359) Eom, Jun Sik, et al. "Metabolomics Comparison of Hanwoo (Bos taurus coreanae) Biofluids Using Proton Nuclear Magnetic Resonance Spectroscopy." Metabolites 10.8 (2020)

360) Jiang, Qiaoying, et al. "Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model." Computational and Structural Biotechnology Journal (2020)

361) Wang, Xiaoqing, et al. "Transcriptomic, proteomic and metabolomic profiling unravel the mechanisms of hepatotoxicity pathway induced by triphenyl phosphate (TPP)." Ecotoxicology and Environmental Safety 205 (2020)

362) Buffagni, Valentina, et al. "Shaping durum wheat for the future: gene expression analyses and metabolites profiling support the contribution of BCAT genes to drought stress response." Frontiers in plant science 11 (2020)

363) Giribaldi, Marzia, et al. "Urinary Metabolomic Profile of Preterm Infants Receiving Human Milk with Either Bovine or Donkey Milk-Based Fortifiers." Nutrients 12.8 (2020)

364) Jeong, Jin Young, et al. "Metabolomics analysis of the beef samples with different meat qualities and tastes." Food Science of Animal Resources (2020)

365) Liu, Wuping, et al. "Metabolomic differences and interactions between coronary heart disease and diabetes mellitus: Pathogenesis understanding and auxiliary diagnosis." (2020)

366) Ganobis, Caroline M., et al. "1D 1H NMR as a Tool for Fecal Metabolomics." Current Protocols in Chemical Biology 12.3 (2020)

367) Yu, Leilei, et al. "Lactobacillus plantarum-Mediated Regulation of Dietary Aluminum Induces Changes in the Human Gut Microbiota: an In Vitro Colonic Fermentation Study." Probiotics and Antimicrobial Proteins (2020)

368) Roques, Simon, et al. "Proton-NMR Metabolomics of Rainbow Trout Fed a Plant-Based Diet Supplemented with Graded Levels of a Protein-Rich Yeast Fraction Reveal Several Metabolic Processes Involved in Growth." The Journal of Nutrition (2020)

369) Mascellani, Anna, et al. "1H NMR chemometric models for classification of Czech wine type and variety." Food Chemistry (2020)

370) Gupta, Latika, et al. "NMR‐based clinical metabolomics revealed distinctive serum metabolic profiles in patients with spondyloarthritis." Magnetic Resonance in Chemistry. (2020)

371) Gisewhite, Sarah Ann. Assessment of Urinary Metabolites in Risk Prediction of Acute Kidney Injury. Diss. University of Minnesota, (2020)

372) Stinson, L. F., et al. "Human milk from atopic mothers has lower levels of short chain fatty acids." Front. Immunol. 11: 1427. doi: 10.3389/fimmu (2020)

373) Coelho, Margarida, et al. "The Potential of Metabolomics in the Diagnosis of Thyroid Cancer." International Journal of Molecular Sciences 21.15 (2020)

374) Boulaka, Athina, et al. "Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota." Molecules 25.15 (2020)

375) Han, Yumei, et al. "Urine metabolomic responses to aerobic and resistance training in rats under chronic unpredictable mild stress." PloS one 15.8 (2020)

376) Meleti, Marco, et al. "Metabolic Profiles of Whole, Parotid and Submandibular/Sublingual Saliva." Metabolites 10.8 (2020)

377) Cho, Soohyun, et al. "Comparison of tastes-related components and eating quality between Hanwoo steer and cow longissimus dorsi muscles." Food Science of Animal Resources (2020).

378) Wagner, Liane, et al. "Comparison of Targeted (HPLC) and Nontargeted (GC-MS and NMR) Approaches for the Detection of Undeclared Addition of Protein Hydrolysates in Turkey Breast Muscle." Foods 9.8 (2020)

379) Berger, Emmanuelle, et al. "Use of nanovesicles from orange juice to reverse diet-induced gut modifications in diet-induced obese mice." Molecular Therapy-Methods & Clinical Development (2020).

380) Bazzano, Marilena, et al. "Exercise Induced Changes in Salivary and Serum Metabolome in Trained Standardbred, Assessed by 1H-NMR." Metabolites 10.7 (2020)

381) Jo, Hyung Ah, et al. "Fumarate modulates phospholipase A2 receptor autoimmunity-induced podocyte injury in membranous nephropathy." Kidney International (2020).

382) Zheng, Hong, et al. "Distinct metabolic signatures of hormone-sensitive and castration-resistant prostate cancer revealed by a 1H NMR-based metabolomics of biopsy tissue." Journal of Proteome Research (2020).

383) Bruzzone, Chiara, et al. "SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum."(2020)

384) Souza, Amanda CL, et al. "Alcoholic beverages from araçá-boi fruit: quantification of antioxidant compounds by NMR ERETIC2." Journal of Food Science and Technology (2020)

385) Parmanand, Bhavika, et al. "Systemic iron reduction by venesection alters the gut microbiome in patients with haemochromatosis." JHEP Reports (2020)

386) Lara, Olivia D., et al. "Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2) in preclinical models of ovarian and uterine cancer." Oncotarget 11.29 (2020)

387) Drabińska, Natalia, et al. "An Optimization of Liquid–Liquid Extraction of Urinary Volatile and Semi-Volatile Compounds and Its Application for Gas Chromatography-Mass Spectrometry and Proton Nuclear Magnetic Resonance Spectroscopy." Molecules 25.16 (2020)

388) Abreu, Ana Cristina, and Ignacio Fernández. "NMR Metabolomics Applied on the Discrimination of Variables Influencing Tomato (Solanum lycopersicum)." Molecules 25.16 (2020)

389) Rotondo, Archimede, Francesca Rigano, and Luigi Mondello. "Comprehensive Chemical Characterization of the Pistacia vera Fruits through Original NMR Quantification Methods." Applied Sciences 10.16 (2020)

390) Hiller, Gregory Walter, and Bhanu Chandra Mulukutla. "METHOD OF CELL CULTURE." U.S. Patent Application No. 16/722,541. (2020)

391) Schuijs, Martijn J., et al. "ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung." Nature immunology (2020)

392) Engleman, Laura, et al. "Shu-en Wu1, 5, Seika Hashimoto-Hill1, 5, Vivienne Woo1, Emily M. Eshleman1, Jordan Whitt1." (2020)

393) Wahida, Adam, et al. "Aberrant TNF Signaling Links RIPK3-Dependent Cell Death and Loss of TLR5 with Intestinal Inflammation and Dysbiosis." (2020)

394) Hlušička, Jiří. "Prospektivní studie role oxidačního stresu u akutních intoxikací metanolem." (2020).

395) Sailwal, Megha, et al. "Connecting the dots: Advances in modern metabolomics and its application in yeast system." Biotechnology Advances (2020)

396) Yilmaz, Ali, et al. "Targeted Metabolic Profiling of Urine Highlights a Potential Biomarker Panel for the Diagnosis of Alzheimer’s Disease and Mild Cognitive Impairment: A Pilot Study." Metabolites 10.9 (2020)

397) Ralha de Abreu, Ana Cristina, and Ignacio Fernández de las Nieves. "NMR Metabolomics Applied on the Discrimination of Variables Influencing Tomato (Solanum lycopersicum)." (2020)

398) Stoffers, Katarina M., et al. "Noninvasive Epidermal Metabolite Profiling." Analytical Chemistry (2020)

399) Raja, Ganesan, et al. "1H-NMR-based metabolomics for cancer targeting and metabolic engineering–A review." Process Biochemistry (2020)

400) Samuelsson, Linda M., et al. "Preparation of drip samples from leg of lamb with extended shelf life for nuclear magnetic resonance metabolomics studies." Meat Science (2020)

401) Huang, Xiaoning, et al. "Composition and Metabolic Functions of the Microbiome in Fermented Grain during Light-Flavor Baijiu Fermentation." Microorganisms 8.9 (2020)

402) Wu, De-Ling, et al. "NMR-based metabolomics approach to study the effects of Wu-Zi-Yan-Zong-Wan on triptolide-induced oligospermia in rats." Journal of Ethnopharmacology (2020)

403) Beachler, T. M., et al. "Metabolomic profile of allantoic and amniotic fluid in late-term gestational mares characterized by 1H-nuclear magnetic resonance spectroscopy." Journal of Equine Veterinary Science (2020)

404) Louvado, A., et al. "Effect of glycerol feed-supplementation on seabass metabolism and gut microbiota." Applied Microbiology and Biotechnology (2020)

405) Rawle, Rachel A., et al. "Metabolic Responses to Arsenite Exposure Regulated through Histidine Kinases PhoR and AioS in Agrobacterium tumefaciens 5A." Microorganisms 8.9 (2020)

406) Zhou, Yi, et al. "Sex-specific Metabolic Characterization of Serum and Liver of Mice with High-fat Diet." (2020)

407) Carbone, Katya, et al. "Microwave-assisted synthesis of catalytic silver nanoparticles by hyperpigmented tomato skins: A green approach." LWT (2020)

408) Ansari, AbuZar, et al. "Identification of Potential Biomarkers in the Cervicovaginal Fluid by Metabolic Profiling for Preterm Birth." Metabolites 10.9 (2020)

409) Bispo, Daniela, et al. "Hormone-Independent Mouse Mammary Adenocarcinomas with Different Metastatic Potential Exhibit Different Metabolic Signatures." Biomolecules 10.9 (2020)

410) Horník, Štěpán, et al. "Nuclear Magnetic Resonance Aerosolomics: A Tool for Analysis of Polar Compounds in Atmospheric Aerosols." ACS Omega (2020)

411) Li, Jiaqi, et al. "Metabolomics Profiling Reveals the Mechanism of Caffeic Acid in Extending Lifespan in Drosophila melanogaster." Food & Function (2020)

412) Pocate-Cheriet, K., et al. "THE Follicular fluid metabolome DIFFERS according to THE endometriosis phenotype." Reproductive BioMedicine Online (2020)

413) Siddiqui, Mohd Adnan, et al. "Metabolomics: An emerging potential approach to decipher critical illnesses." Biophysical Chemistry (2020)

414) Collins, Bradley J., et al. "Comparison of phytochemical composition of Ginkgo biloba extracts using a combination of non-targeted and targeted analytical approaches." Analytical and Bioanalytical Chemistry (2020)

415) Carbone, Katya, et al. "Exploring the potential of microwaves and ultrasounds in the green extraction of bioactive compounds from Humulus lupulus for the food and pharmaceutical industry." Industrial Crops and Products 156 (2020)

416) Hasegawa, Yu, et al. "Optimization of a Method for the Simultaneous Extraction of Polar and Non-Polar Oxylipin Metabolites, DNA, RNA, Small RNA, and Protein from a Single Small Tissue Sample." Methods and Protocols 3.3 (2020)

417) Chen, Xu, et al. "Self-assembling Cyclodextrin-based Nanoparticles Enhance the Cellular Delivery of Hydrophobic Allicin." Journal of Agricultural and Food Chemistry (2020)

418) Dong, Chaoran, et al. "Correlation Network Analyses Based on Metagenomics and Multi-type Metabolomic Data Identified Biomarkers of Coronary Artery Disease." (2020)

419) Ooi, Theng Choon, et al. "Intermittent Fasting Enhanced the Cognitive Function in Older Adults with Mild Cognitive Impairment by Inducing Biochemical and Metabolic changes: A 3-Year Progressive Study." Nutrients 12.9 (2020)

420) Aksentijević, Dunja, et al. "Intracellular sodium elevation reprograms cardiac metabolism." Nature Communications 11.1 (2020)

421) Martinez, Paula J., et al. "Urinary metabolic signatures reflect cardiovascular risk in the young, middle-aged, and elderly populations." Journal of Molecular Medicine (2020)

422) Huang, Bo‐Yuan, et al. "Longitudinal change of metabolite profile and its relation to multiple risk factors for the risk of developing hepatitis B‐related hepatocellular carcinoma." Molecular Carcinogenesis. (2020)

423) Hasegawa, Yu, et al. "Long-term effects of western diet consumption in male and female mice." Scientific Reports 10.1 (2020)

424) De Castro, Federica, et al. "Visible light-activated water-soluble Platicur nanocolloids: photocytotoxicity and metabolomics studies in cancer cells." ACS Applied Bio Materials (2020)

425) Suzuki, Takafumi, et al. "Nrf2 contributes to the weight gain of mice during space travel." Communications Biology 3.1 (2020)

426) Simard, Chloé, et al. "Metabolic Characterization and Consequences of Mitochondrial Pyruvate Carrier Deficiency in Drosophila melanogaster." Metabolites 10.9 (2020)

427) Gu, Jinping, et al. "Nuclear magnetic resonance‐based tissue metabolomic analysis clarifies molecular mechanisms of gastric carcinogenesis." Cancer science 111.9 (2020)

428) Petras, Martin, et al. "NMR plasma metabolomics study of patients overcoming acute myocardial infarction: in the first 12 h after onset of chest pain with statistical discrimination towards metabolomic biomarkers." Physiological research. (2020)

429) Sanches, Monique Lalue, et al. "1H-NMR-Based salivary metabolomics from females with temporomandibular disorders–A pilot study." Clinica Chimica Acta 510 (2020)

430) Zhang, Yu, et al. "Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer." Journal of Experimental Medicine 217.12 (2020).

431) Biagi, Elena, et al. "Effects of Vitamin B2 Supplementation in Broilers Microbiota and Metabolome." Microorganisms 8.8 (2020)

432) Catlett, Jennie L., et al. "Metabolic Feedback Inhibition Influences Metabolite Secretion by the Human Gut Symbiont Bacteroides thetaiotaomicron." mSystems 5.5 (2020)

433) Singh, Yogesh, et al. "SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of immune cells." bioRxiv (2020)

434) Villa-Ruano, Nemesio, et al. "Study of nutritional quality of pomegranate (Punica granatum L.) juice using 1H NMR-based metabolomic approach: A comparison between conventionally and organically grown fruits." LWT (2020)

435) Lensu, Sanna, et al. "Prebiotic Xylo-oligosaccharides Targeting Faecalibacterium prausnitzii Prevent High Fat Diet-induced Hepatic Steatosis in Rats." (2020)

436) Mal, Tapas K., Yuan Tian, and Andrew D. Patterson. "Sample Preparation and Data Analysis for NMR-Based Metabolomics." Translational Bioinformatics for Therapeutic Development. Humana, New York, NY (2020)

437) Laserna, Anna Karen Carrasco, et al. "Metabolic Profiling of a Porcine Combat Trauma-Injury Model Using NMR and Multi-Mode LC-MS Metabolomics—A Preliminary Study." Metabolites 10.9 (2020)

438) Ahmad Azam, Amalina, et al. "The anti-neuroinflammatory effects of Clinacanthus nutans leaf extract on metabolism elucidated through 1H NMR in correlation with cytokines microarray." PloS one 15.9 (2020)

439) Конанов, Д. Н., et al. "ПРИМЕНИМОСТЬ МЕТОДА 1H ЯМР ДЛЯ ПОИСКА МЕТАБОЛОМНЫХ МАРКЕРОВ НА ПРИМЕРЕ ПРЕДСКАЗАНИЯ УСПЕШНОСТИ АНТИ-PD-1 ТЕРАПИИ. THE APPLICABILITY OF THE 1H NMR METHOD FOR THE SEARCH FOR METABOLOMIC MARKERS BY THE EXAMPLE OF PREDICTING THE SUCCESS." (2020)

440) Asri, Nursyafiqah Mohamad, et al. "Low molecular weight peptides generated from palm kernel cake via solid state lacto-fermentation extend the shelf life of bread." LWT (2020)

441) Attia, Imen Ben, et al. "Evaluation of the antioxidant and cytotoxic activities on cancer cell line of extracts of parasitic plants harvested in Tunisia." Polish Journal of Food and Nutrition Sciences 70.3 (2020)

442) Berezovskaya, Yuliya, et al. "Biotic nutritional components in baby formula: possible solution for infantile colic management." Functional Foods in Health and Disease 10.9 (2020)

443) Parmanand, Bhavika, et al. "Systemic iron reduction by venesection alters the gut microbiome in Haemochromatosis patients." Journal of Hepatology Reports (2020)

444) Chang‐Chien, Ju, et al. "MetabolomicDifferences of Exhaled Breath Condensate AmongChildren With and WithoutAsthma." Pediatric Allergy and Immunology. (2020)

445) Nik Mohd Fakhruddin, Nik Nur Izzati, et al. "Urine Untargeted Metabolomic Profiling Is Associated with the Dietary Pattern of Successful Aging among Malaysian Elderly." Nutrients 12.10 (2020)

446) Mozuraityte, Revilija, et al. "Superchilled, chilled and frozen storage of Atlantic mackerel (Scomber scombrus)–effect on lipids and low molecular weight metabolites." International Journal of Food Science & Technology. (2020)

447) Mannaa, Mohamed, Young-Su Seo, and Inmyoung Park. "Addition of Coriander during Fermentation of Korean Soy Sauce (Gangjang) Causes Significant Shift in Microbial Composition and Reduction in Biogenic Amine Levels." Foods 9.10 (2020)

448) Mistry, Priya, et al. "Circadian influence on the microbiome improves heart failure outcomes." Journal of Molecular and Cellular Cardiology (2020)

449) Zhao, Chang, et al. "Metabolic alterations in dairy cows with subclinical ketosis after treatment with carboxymethyl chitosan‐loaded, reduced glutathione nanoparticles." Journal of Veterinary Internal Medicine. (2020)

450) Petrella, Greta, et al. "The Interplay Between Oxidative Phosphorylation and Glycolysis as a Potential Marker of Bladder Cancer Progression in Vitro and in Vivo." (2020).

451) Wu, Shu-en, et al. "Microbiota-derived metabolite promotes HDAC3 activity in the gut." Nature (2020)

452) Nguyen, Quang P., et al. "Multi-omic characterization of the taxa-function relationship in infant gut microbiomes." (2020)

453) Tardivel, Patrick, Rémi Servien, and Didier Concordet. "Powerful multiple testing procedures derived from hyperrectangular confidence regions. (2020)

454) Lee, Wonho, et al. "Machine learning for a rapid discrimination of ginseng cultivation age using 1 H-NMR spectra." Applied Biological Chemistry 63.1 (2020)

455) Zhang, Yaxin, et al. "Dingxin Recipe IV attenuates atherosclerosis by regulating lipid metabolism through LXR-α/SREBP1 pathway and modulating the gut microbiota in ApoE-/-mice fed with HFD." Journal of Ethnopharmacology (2020)

456) Huang, Meng-Sen, et al. "SLC38A2 overexpression induces cancer‐like metabolic profile and cooperates with SLC1A5 in pan‐cancer prognosis." Chemistry–An Asian Journal. (2020)

457) Seo, Jong Bok, and Sung-Gil Chi. "KCNJ11 downregulation stimulates cardiac cell apoptosis in myocarditis."(2020)

458) Kioroglou, Dimitrios, Albert Mas, and Maria C. Portillo. "Qualitative Factor-Based Comparison of NMR, Targeted and Untargeted GC-MS and LC-MS on the Metabolomic Profiles of Rioja and Priorat Red Wines." Foods 9.10 (2020)

459) Dallons, Matthieu, et al. "GPR91 Receptor Mediates Protection against Doxorubicin-Induced Cardiotoxicity without Altering Its Anticancer Efficacy. An In Vitro Study on H9C2 Cardiomyoblasts and Breast Cancer-Derived MCF-7 Cells." Cells 9.10 (2020)

460) Netrprachit, Papichaya, et al. "Metabolite Profiles of Red and White Rice Aqueous Extracts Derived at Different Temperatures and Their Relationship with Biological Properties as Determined Using 1H-NMR-Based Metabolomics Analysis."(2020)

461) 冯雪, et al. "基于 1 H NMR 代谢组学的黄芩茶与黄芩叶水提物延长果蝇寿命研究." 药学学报 55.6 (2020)

462) Singh, Yogesh, et al. "DJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)." Scientific Reports 10.1 (2020)

463) Kim, Kyung Hyun, et al. "Identification of biogenic amine-producing microbes during fermentation of ganjang, a Korean traditional soy sauce, through metagenomic and metatranscriptomic analyses." Food Control (2020)

464) O’Callaghan, Tom F., et al. "The bovine colostrum and milk metabolome at the onset of lactation as determined by 1H-NMR." International Dairy Journal (2020)

465) Piras, C., et al. "Analysis of metabolomics profile in hypothyroid patients before and after thyroid hormone replacement." Journal of Endocrinological Investigation (2020)

466) NORA, LAREF. "EFFICIENCY OF DIFFERENT BIOINFORMATICS TOOLS IN METABOLITE PROFILING OF WHOLE COW’S MILK USING SYNTHETICALLY WATER-REMOVED 1H NMR SPECTRA: A COMPARATIVE STUDY." Journal of Microbiology, Biotechnology and Food Sciences 2020 (2020)

467) Liu, Pu, et al. "Metabolic profiling reveals local and systemic responses of kiwifruit to Pseudomonas syringae pv. actinidiae." Authorea Preprints (2020)

468) Phophi, Sehlakgwe, Namrita Lall, and Gerhard Prinsloo. "H-1-NMR metabolomics and LC-MS analysis to determine seasonal variation in a cosmeceutical plant Leucosidea sericea." (2020)

469) Oliver, Josidel Conceição, et al. "Metabolic profiling of Candida clinical isolates of different species and infection sources." Scientific Reports 10.1 (2020)

470) Duft, Renata G., et al. "Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance." Scientific Reports 10.1 (2020)

471) Joseph, David, et al. "Rapid NMR data acquisition with improved resolution and sensitivity for high‐throughput metabolomic analysis." Magnetic Resonance in Chemistry. (2020)

472) Gandra, Jefferson R., et al. "Metabolome fingerprints, performance and carcass quality of beef calves supplemented with antibiotic free additive." Animal Biotechnology (2020)

473) Gómez, Valentí, et al. "Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells." Science Signaling 13.652 (2020)

474) Heitzman, Jackie A., et al. "A 1 H-NMR approach to myocardial energetics." Scientific Reports 10.1 (2020)

475) Yoon, Dahye, et al. "Serum Metabonomic Research of the Anti-Hypertensive Effects of Ogaja on Spontaneously Hypertensive Rats." Metabolites 10.10 (2020)

476) Pereira, Giuliano E., et al. "Impact of grapevine red blotch disease on primary and secondary metabolites in ‘Cabernet Sauvignon’grape tissues." Food Chemistry (2020)

477) Cônsolo, Nara Regina Brandão, et al. "Preliminary study on the characterisation of Longissimus lumborum dark cutting meat in Nellore cattle using NMR-based metabolomics." Meat Science (2020)

478) Fuchs, Amanda L., et al. "Pseudomonas aeruginosa Planktonic-and Biofilm-Conditioned Media Elicit Discrete Metabolic Responses in Human Macrophages." Cells 9.10 (2020)

479) Guidi, Alessandra, et al. "Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy." PLOS Neglected Tropical Diseases 14.10 (2020)

480) Shin, Min-Ji, et al. "Kemeny–Snell Distance in Nuclear Magnetic Resonance Metabolomics." Applied Magnetic Resonance (2020)

481) Nazarudin, Muhammad Farhan, et al. "Metabolic variations in seaweed, Sargassum polycystum samples subjected to different drying methods via 1H NMR-based metabolomics and their bioactivity in diverse solvent extracts." Arabian Journal of Chemistry (2020)

482) Nemadodzi, Lufuno Ethel, Jacques Vervoort, and Gerhard Prinsloo. "NMR-Based Metabolomic Analysis and Microbial Composition of Soil Supporting Burkea africana Growth." Metabolites 10.10 (2020)

483) Coates, Laurynne C., et al. "Development on Citrus medica infected with ‘Candidatus Liberibacter asiaticus’ has sex-specific and-nonspecific impacts on adult Diaphorina citri and its endosymbionts." PloS one 15.10 (2020)

484) Kwon, Hyuk Nam, et al. "Screening for Early Gastric Cancer Using a Noninvasive Urine Metabolomics Approach." Cancers 12.10 (2020)

485) Simard, Chloé J., et al. "Role of the Mitochondrial Pyruvate Carrier in the Occurrence of Metabolic Inflexibility in Drosophila melanogaster Exposed to Dietary Sucrose." Metabolites 10.10 (2020)

486) Sheriff, Lozan, et al. "Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2-/-animals." Disease Models & Mechanisms (2020)

Case Studies

The case studies below showcase various studies that were performed using Chenomx technology and services.

 

Analyzing the Metabolic Effects of Acetaminophen

 

Developing Biomarkers for Adverse Drug Responses

 

Pathways From Serological Metabolite Profiles

Acetaminophen is the most common identifiable cause of acute liver failure, and is an excellent model compound for studying liver toxicity. Acetaminophen toxicity has thus become a very active area of research. Identifying and quantifying metabolites associated with acetaminophen toxicity is an integral part of this research, and Chenomx is uniquely equipped to extract this information from biofluid samples.

Drug-induced liver injury is the leading reason that drug candidates fail. Identifying a suite of toxicity biomarkers for use in preclinical screening of drug candidates will allow drugs with harmful side effects to be identified earlier. Biomarkers that can be used to monitor or stage diseases will also offer insight into the net metabolic effect of a drug and can provide information for developing new drugs or adjusting treatment. Chenomx software offers powerful tools to aid in identifying these biomarkers.

Metabolomic data sets obtained using Chenomx NMR Suite often require additional analysis to place them in proper context. The GeneGo pathway analysis platform can help establish this context. In this note, we present an example analysis using serological metabolic profiles from Chenomx NMR Suite, known inflammatory markers from prior studies of the K/BxN mouse model and the GeneGo platform to generate a mechanistic hypothesis for the K/BxN mouse model.

Application Notes

Methods

Accurate CSI Quantification for Targeted Profiling

Accurately quantifying metabolites using targeted profiling in Chenomx NMR Suite requires using a chemical shape and shift indicator (CSI) of known concentration. As a result, the accuracy of the CSI concentration has a significant influence on quantification accuracy using this technique. Measuring ratios of the CSI peak area with that of a second, commercially available standard under optimal acquisition conditions offers a simple method of accurately measuring the concentration of the CSI.

 Optimizing Spectra for Metabolomics

Chenomx Processor allows you to work with NMR spectra from a variety of sources, helping you apply phasing and baseline correction through manual and semi-automated tools, and offering advanced lineshape correction through reference deconvolution. Processor also allows you to define chemical shape indicator (CSI) parameters and determine sample pH via indicator compounds. These are necessary prerequisites to analyzing your spectra with Chenomx Profiler.

Sample Types

Targeted Profiling of Common Metabolites in Saliva

Saliva is an excellent biofluid for analysis by targeted profiling. It is easily collected by individuals with minimal training, using noninvasive techniques. Targeted profiling of saliva samples can provide identification and quantification of many of the small molecule metabolites commonly found in saliva, and may allow the development of simple screening procedures for a variety of diseases. In this note we present a list of common metabolites found in human saliva, and techniques for targeted profiling of saliva spectra with Chenomx NMR Suite.

Metabolites in Blood Serum and Plasma

Blood serum and plasma are biofluids that are increasingly important in NMR-based metabolomics analysis. In this note we discuss several approaches to the analysis of serum using Chenomx NMR Suite, focusing on relaxation-edited NMR (CPMG) and physical separation of protein and metabolites using ultrafiltration. The CPMG method is simpler to apply, but the spectra are easier to analyze when protein is removed from a sample.

 

Targeted Profiling of Common Metabolites in Urine

Urine is a readily-collected, information-rich biofluid that can provide insight into the metabolic state of an organism. As a result, urine is often a focus in metabolomics investigations using NMR and MRI spectroscopy, in both diagnostic and monitoring applications. Targeted profiling is a powerful tool that can drive such studies, providing direct identification and quantification of a variety of metabolites. In this note we present a list of common metabolites found in many NMR spectra of human urine and several strategies for approaching targeted profiling of such spectra with Chenomx NMR Suite.

 

Identifying Metabolites in Biofluids

In this note we present a rapid, efficient method for identifying metabolites in biofluid NMR spectra using targeted profiling. Conventional techniques for identifying and quantifying metabolites in such spectra are labor-intensive and error-prone, as positions and linewidths of peaks can vary widely with changes in pH and other solution matrix effects. The length of time and level of operator skill needed to analyze large numbers of these complex spectra are significant barriers to the widespread application of NMR in metabolomics.

Statistical Analysis

Statistical Analysis of Targeted Profiling Data

Analysis of 1H NMR spectra in metabolomics studies often requires multivariate pattern recognition techniques to extract meaningful results. Targeted profiling offers the ability to analyze spectra based directly on the identity and quantities of individual compounds. Profiles created using targeted profiling in Chenomx NMR Suite can be used as input in statistical software packages such as Umetrics SIMCA-P. Performing PCA on Chenomx targeted profiles yields information-rich results that allow rapid biological interpretation, since group separation can be directly correlated to variations in specific metabolite concentrations.

Correcting Lineshapes in NMR Spectra

In this note we present a method for removing lineshape distortions from nuclear magnetic resonance (NMR) spectra prior to more detailed analysis. Reference deconvolution is a method of reconstructing an ideal spectrum by removing lineshape distortions caused by field inhomogeneity. Applying reference deconvolution has been found to improve the quality of fit of a spectrum using targeted profiling in Chenomx NMR Suite. However, successful application of reference deconvolution to a spectrum requires some preprocessing and the presence of an appropriate reference peak.

 

Statistical Analysis of Spectral Binning Data

Analysis of 1H NMR spectra in metabolomics studies often requires multivariate pattern recognition techniques to extract meaningful results. Spectral binning is an effective data reduction technique commonly used to prepare spectra for multivariate analysis. Spectral binning output from the Profiler module of Chenomx NMR Suite can readily be analyzed with multivariate analysis software packages like Umetrics SIMCA-P.